SGK1
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Official Full Name
serum/glucocorticoid regulated kinase 1 -
Overview
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
SGK1;serum/glucocorticoid regulated kinase 1;serum/glucocorticoid regulated kinase , SGK;serine/threonine-protein kinase Sgk1;serine/threonine protein kinase SGK;serum/glucocorticoid-regulated kinase 1;SGK
Recombinant Proteins
- Mouse
- Human
- Chicken
- Zebrafish
- E.coli
- Insect Cells
- Sf9 Cells
- Hi-5 Insect Cells
- Mammalian Cells
- HEK293
- His
- GST
- Non
- T7
- DDK
- Myc
- Avi
- Fc
Involved Pathway
SGK1 involved in several pathways and played different roles in them. We selected most pathways SGK1 participated on our site, such as FoxO signaling pathway,PIK-Akt signaling pathway,Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | MET,PPP2R3C,SGK3,FGF5,GNG12,GNGT2,LAMC2,TP53,FGF17,ITGB4 |
| FoxO signaling pathway | IGF1RB,FOXO4,PRMT1,PLK4,PLK2,SGK2A,PTENA,CCNB2,KRAS,RAF1 |
| Aldosterone-regulated sodium reabsorption | ATP1B1,IRS1,INS,KCNJ1,MAPK1,INS2,PRKCB,INS1,ATP1B2,FXYD2 |
Protein Function
SGK1 has several biochemical functions, for example, ATP binding,calcium channel regulator activity,chloride channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SGK1 itself. We selected most functions SGK1 had, and list some proteins which have the same functions with SGK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCB6,DHX30,PAPSS2B,DCLK1,P2RX4B,FAM20B,STK36,EPHB2,MAP4K6,UBE2NA |
| chloride channel regulator activity | SGK3,SGK2A,BSND,CHRNA7,SGK2,SLC9A3R1,SGK2B |
| calcium channel regulator activity | SRI,CACNA2D2,STIM2,SGK2,NPY2R,CACNA2D3,PLN,SGK3,TSPAN13,CAV3 |
| potassium channel regulator activity | SUMO1,AMIGO1,KCNE1L,LRRC26,KCNIP4,KCNMB2,CHP,KCNMB1,KCNE1,AKAP9 |
| protein binding | GRIN2A,CYFIP2,ITM2A,TMEM25,MEAF6,BACE1,GGA3,KCNQ1,CERK,YOD1 |
| protein serine/threonine/tyrosine kinase activity | PRKACA,CLK1,CLK4,DYRK1AA,DYRK3,DYRK1B,DYRK2,AURKC,MAP2K1,PRKCG |
| sodium channel regulator activity | PRSS30,RANGRF,CAV3,FXYD6,YWHAH,FGF13,SCN3B,SCN1BB,FXYD3,SGK3 |
| protein serine/threonine kinase activity | PRKACAB,IRAK2,PRKY,EIF2AK4,TTBK2,ROCK2A,GSK3A,TSSK5,STK35L,RPS6KB2 |
Interacting Protein
SGK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGK1.
CREB1;RABAC1;PDPK1;GADD45G;MAPT;IKBKG;Tcr-alpha;13514813;PPIAL4D;EIF3F;PFAS;CS;CBR3;LETM1
SGK1 Related Signal Pathway
Resources
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References
- Heller, BA; Ghidinelli, M; et al. Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. JOURNAL OF CELL BIOLOGY 204:1219-1236(2014).
- Qadri, SM; Su, Y; et al. Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal. CARDIOVASCULAR DIABETOLOGY 13:-(2014).
