SET

  • Official Full Name

    SET nuclear oncogene

  • Overview

    The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    SET;SET nuclear oncogene;SET translocation (myeloid leukemia associated);protein SET;2PP2A;IPP2A2;PHAPII;protein phosphatase type 2A inhibitor;Template Activating Factor I;chromatin remodelling factor;HLA-DR-associated protein II;phosphatase 2A

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Rat
  • Mammalian Cell
  • E.coli
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • GST
  • Flag
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
SET-14976M Recombinant Mouse SET Protein Mammalian Cell Mouse His
SET-2047H Recombinant Human SET Nuclear Oncogene E.coli Human Non
SET-2048H Recombinant Human SET Nuclear Oncogene, GST-tagged E.coli Human GST
SET-237H Recombinant Human SET nuclear oncogene, His-tagged E.coli Human His 1-290 a.a.
SET-2394C Recombinant Chicken SET Mammalian Cell Chicken His
SET-2446H Recombinant Human SET Nuclear Oncogene, GST-tagged E.coli Human GST
SET-30076TH Recombinant Human SET Wheat Germ Human Non 277 amino acids
SET-5348R Recombinant Rat SET Protein Mammalian Cell Rat His
SET-1928HCL Recombinant Human SET 293 Cell Lysate HEK293 Human Non
SET-02HFL Recombinant Full Length Human SET nuclear oncogene Protein, Flag tagged HEK293 Human Flag Full L. 1-290 aa
Set-13MFL Recombinant Full Length Mouse SET nuclear oncogene Protein, Flag tagged HEK293 Mouse Flag Full L. 1-289 aa
SET-466HF Recombinant Full Length Human SET Protein In Vitro Cell Free System Human Full L. 277 amino acids
SET-5007R Recombinant Rat SET Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
SET-5007R-B Recombinant Rat SET Protein Pre-coupled Magnetic Beads HEK293 Rat
Set-5797M Recombinant Mouse Set Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
SET-5914H Recombinant Human SET Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
SET-8065M Recombinant Mouse SET Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SET-8065M-B Recombinant Mouse SET Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SET involved in several pathways and played different roles in them. We selected most pathways SET participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Condensation of Prophase Chromosomes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SET were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression HNRNPH1,ASZ1,MED6,PTBP1,ZNF485,LAGE3,ZNF776,ZNF256,ZNF230,ZNF558
    Mitotic Prophase NEK9,ENSAA,NEK6,SETA,ENSAB,GORASP2,MASTL,VRK1,SETB,ARPP19B
    M Phase NIPBLB,PHF8,B9D2,CTDNEP1B,SETA,NSL1,CENPE,SKA2,CTDNEP1,NCAPD3
    Cell Cycle, Mitotic ODF2,TUBG1,CENPI,GOLGA2,ZWILCH,DULLARD,HIST4H4,SPDL1,NUF2,MAPRE1
    Cell cycle YWHAQ,TFDP1,TOP2A,CCND3,RAD9B,LIN9,NEK9,CCNE1,GMNN,YWHAE1
    Condensation of Prophase Chromosomes PHF8,SMC2,NCAPD3,H3F3B.1,NCAPG2,SETA,MCPH1,NCAPH2,SMC4,H3F3D
    Regulation of mRNA stability by proteins that bind AU-rich elements SETA,ANP32A,TNPO1,SETB,KHSRP,ELAVL1,ZFP36L1,ZFP36L1A,HUG,ZFP36L1B
    HuR (ELAVL1) binds and stabilizes mRNA HUG,ELAVL1,ANP32A,SETB,SETA

    Protein Function

    SET has several biochemical functions, for example, DNA binding,histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SET itself. We selected most functions SET had, and list some proteins which have the same functions with SET. You can find most of the proteins on our site.

    Function Related Protein
    protein phosphatase type 2A regulator activity PPP2R5CB,PPP2R5D,PPP2R2B,pab1,PPP2R5B,PPP2R5EB,PPP2R2CA,PPP2R5EA,ENSA,PPP2R5E
    protein phosphatase inhibitor activity PPP1R27,PPP1R1C,PPP1R36,PTN,GLC8,URI1,SAG,ENSAA,PPP1R10,ARPP19
    DNA binding BRCA1,POLM,TCEA1,HIST1H3F,SOX15,HIST1H2BC,FOXD1,NR5A1,PCGF2,POU3F2A
    protein binding RNF185,MED9,C20orf20,HTR1B,BCL2L11,EPHA4,HLA-A,C19orf44,C6orf211,GATAD2B
    histone binding Ctsl,TBL1X,HIST1H4C,BAZ2A,CD1d1,SFMBT1,ASF1B,NCL,HIST1H4A,ASF1A

    Interacting Protein

    SET has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SET here. Most of them are supplied by our site. Hope this information will be useful for your research of SET.

    THAP7;RAC1;UBTF;TBP

    Resources

    References

    • Garay, AM; Lachos, VH; et al. Bayesian estimation and case influence diagnostics for the zero-inflated negative binomial regression model. JOURNAL OF APPLIED STATISTICS 42:1148-1165(2015).
    • Signorile, PG; Baldi, A; et al. A Tissue Specific Magnetic Resonance Contrast Agent, Gd-AMH, for Diagnosis of Stromal Endometriosis Lesions: A Phase I Study. JOURNAL OF CELLULAR PHYSIOLOGY 230:1270-1275(2015).

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