SERPINB6
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Official Full Name
serpin peptidase inhibitor, clade B (ovalbumin), member 6 -
Overview
The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
SERPINB6;serpin peptidase inhibitor, clade B (ovalbumin), member 6;deafness, autosomal recessive 91 , DFNB91, PI6, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6;serpin B6;CAP;cytoplasmic antiproteinase;PTI;MGC111370;MSTP057;Peptidase inhibitor 6;PI 6;PI-6;PI6;Placental thrombin inhibitor;Protease inhibitor 6;Protease inhibitor 6 (placental thrombin inhibitor);Serpin peptidase inhibitor clade B (ovalbumin) member 6;SPB6_HUMAN;serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6;SPI3;DFNB91
Recombinant Proteins
- Human
- Chicken
- Cynomolgus
- E.coli
- Insect Cells
- Mammalian Cell
- Insect Cell
- HEK293
- HEK293T
- E. coli
- His
- Non
- Myc&DDK
- His&Trx
- His&Fc&Avi
Involved Pathway
SERPINB6 involved in several pathways and played different roles in them. We selected most pathways SERPINB6 participated on our site, such as Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINB6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | C8G,PIK3CG,LAMA1,GNA15,SERPINB1B,COL4A5,CD1d1,TGFB3,GM-CSF,HSPB1 |
Protein Function
SERPINB6 has several biochemical functions, for example, protease binding,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINB6 itself. We selected most functions SERPINB6 had, and list some proteins which have the same functions with SERPINB6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | KAL1,SPOCK1,SERPINA1E,SERPINA6,RECK,Serpina1c,SERPINB8,SERPINB5,PCSK1NL,MUG2 |
| protease binding | TIMP2B,ADAMTSL4,SRI,IL1R1,PYCARD,Casp3,DPP4,ANXA2,TP53,HSPA6 |
Interacting Protein
SERPINB6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINB6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINB6.
CEP170P1;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
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References
- Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
- Strik, MCM; Wolbink, A; et al. Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. BLOOD 103:2710-2717(2004).
