SCARB2
-
Official Full Name
scavenger receptor class B, member 2 -
Overview
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] -
Synonyms
SCARB2;scavenger receptor class B, member 2;AMRF;EPM4;LGP85;CD36L2;HLGP85;LIMP-2;LIMPII;SR-BII;lysosome membrane protein 2;LIMP II;CD36 antigen-like 2;lysosome membrane protein II;85 kDa lysosomal membrane sialoglycoprotein;85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2;CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II)
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- Mus musculus
- HEK293
- Human Cell
- Mammalian cells
- Mammalian Cell
- E.coli expression system
- E.coli
- HEK293T
- His
- His&Fc
- Fc
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- N-His&C-Myc
Involved Pathway
SCARB2 involved in several pathways and played different roles in them. We selected most pathways SCARB2 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCARB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | ARSA,HEXA,NEU1,CTSSA,AP1S3B,HEXB,DNASE2,ACP5A,PSAPL1,SLC11A2 |
Protein Function
SCARB2 has several biochemical functions, for example, enzyme binding,protein binding,virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCARB2 itself. We selected most functions SCARB2 had, and list some proteins which have the same functions with SCARB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| virus receptor activity | ITGB5,CD86,SLC52A2,TNFRSF14,SERPINB3,ITGB7,GPR172B,ITGB1,HTR2A,GYPA |
| protein binding | KRT17,MTX2,BCAR3,CIRH1A,HMGA2,DDX42,CX3CR1,SUGT1,DDB2,ZNF599 |
| enzyme binding | PRKCA,DDX5,CRB2,TSPAN5,PRKCD,Il6ra,TSPYL1,A2M,CYP2C19,THRB |
Interacting Protein
SCARB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCARB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCARB2.
Gba;PLCG1;CSK;CAV1;q7cj43_yerpe;b3xyc5_sollc;pi3p;A2M;cona_canen;EIF2AK2;ATP6V1A;PRPF8;PNKD;SMC6;MYOF
Resources
Related Services
Related Products
References
- Fink, IR; Benard, EL; et al. Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp. MOLECULAR IMMUNOLOGY 63:381-393(2015).
- Fu, YJ; Aida, I; et al. Progressive myoclonus epilepsy: extraneuronal brown pigment deposition and system neurodegeneration in the brains of Japanese patients with novel SCARB2 mutations. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 40:551-563(2014).
