RPS6KA4
-
Official Full Name
ribosomal protein S6 kinase, 90kDa, polypeptide 4 -
Overview
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] -
Synonyms
RPS6KA4;ribosomal protein S6 kinase, 90kDa, polypeptide 4;MSK2;RSK-B;ribosomal protein S6 kinase alpha-4;RSKB;S6K-alpha-4;ribosomal protein kinase B;ribosomal protein S6 kinase alpha 4;90 kDa ribosomal protein S6 kinase 4;mitogen- and stress-activated protein kinase 2;nuclear mitogen- and stress-activated protein kinase 2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- Insect (sf21)
- Insect cells
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
RPS6KA4 involved in several pathways and played different roles in them. We selected most pathways RPS6KA4 participated on our site, such as MAPK signaling pathway,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | DUSP8A,MAP2K2B,TGFB3,FGF6A,IKBKG,MAPK8IP3,FGF22,MAPT,CACNA1D,RAF1B |
| TNF signaling pathway | VCAM1,CXCL1,MAP3K5,PIK3R2,CREB3L1,MMP14,PTGS2,PGAM5,IL15,TNF |
Protein Function
RPS6KA4 has several biochemical functions, for example, ATP binding,histone kinase activity (H3-S10 specific),magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA4 itself. We selected most functions RPS6KA4 had, and list some proteins which have the same functions with RPS6KA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone kinase activity (H3-S10 specific) | VRK1,RPS6KA5 |
| mitogen-activated protein kinase p38 binding | TAB1,SPAG9,NFATC1,PRMT1 |
| magnesium ion binding | PIF1,CDC42BPG,EPHX2,ZNF143B,THTPA,PPA2,PINK1,STK36,MAP3K5,IDH3G |
| ATP binding | ABCE1,PRPF4BA,MAP3K12,RAD51C,AFG3L2,UBE2G1A,IFIH1,AK7A,EIF2AK4,YRK |
| protein serine/threonine kinase activity | AKT2L,TSSK5,MAST2,MAP4K3,BMPR1AB,KALRN,Aatk,PSKH1,DYRK1A,PRKACAB |
| ribosomal protein S6 kinase activity | RPS6KA3A,RPS6KB1,RPS6KB1B,RPS6KA6,RPS6KA3B,RPS6KA2,RPS6KA3,ALPK2,RPS6KB2,RPS6KA1 |
| protein binding | HHIPL2,NOS3,MIB1,ELP3,MXD1,DLAT,FAF1,BBS5,CCDC28B,TARDBP |
Interacting Protein
RPS6KA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA4.
MAPK14;MAPK3;pi3p;linkable sunitinib analogue;purvalanol b;midostaurin;SNW1;CDC37;CDC5L
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