RPS19
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Official Full Name
ribosomal protein S19 -
Overview
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. -
Synonyms
RPS19;ribosomal protein S19;40S ribosomal protein S19;DBA;Diamond Blackfan anemia;S19;DBA1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
RPS19 involved in several pathways and played different roles in them. We selected most pathways RPS19 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPS6,RPS27.1,RPL7A,RPS5,MRPL27,MRPL17,RPL36AL,RPL10L,RPS8A,RPL4 |
Protein Function
RPS19 has several biochemical functions, for example, fibroblast growth factor binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS19 itself. We selected most functions RPS19 had, and list some proteins which have the same functions with RPS19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of ribosome | RPL34,MRPL12,MRPS18B,MRPL21,RPS23,NDUFA7,RPL9,RPL36AL,SLC25A15A,RPL26L1 |
| protein homodimerization activity | XPA,GSTZ1,GREM2,MFF,RASGRP1,PTPRE,ANO2,GSTA4,ABCB10,PDCD6IP |
| protein binding | MLF1IP,CNTF,E2F1,FANCC,SMPD1,TAF2,MECOM,NCOA2,NPHS1,IRF2BP1 |
| fibroblast growth factor binding | GLG1B,FGFRL1,KLB,Api5,FGFR1,FGFBP3,FGFBP1,PTPRZ1,CEP57,FGFR3 |
| poly(A) RNA binding | PCBP4,RRS1,DDX50,MRPS26,HIST1H4F,GRWD1,SFRS9,MRPS11,DCD,NOLC1 |
| protein kinase binding | JTB,CDH2,CCND3,KCNA5,CCNL1B,FGFR1OP,SMAD1,PAK2,CAMK2N1,PDCD10 |
Interacting Protein
RPS19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS19 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS19.
PIM1;VCAM1;MAGEB2;EIF1B;GH1;FGF2;NME2;VHL;ACTB;CNBP
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References
- Nishiura, H; Chen, J; et al. Base of molecular mimicry between human ribosomal protein S19 dimer and human C5a anaphylatoxin. INTERNATIONAL IMMUNOPHARMACOLOGY 10:1541-1547(2010).
- Badhai, J; Frojmark, AS; et al. Posttranscriptional down-regulation of small ribosomal subunit proteins correlates with reduction of 18S rRNA in RPS19 deficiency. FEBS LETTERS 583:2049-2053(2009).
