RNF41
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Official Full Name
ring finger protein 41 -
Overview
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. -
Synonyms
RNF41;ring finger protein 41;E3 ubiquitin-protein ligase NRDP1;SBBI03;4930511A05Rik;4933415P08Rik;E3 ubiquitin protein ligase NRDP1;Fetal Liver RING finger protein;FLRF;MGC45228;Neuregulin receptor degradation protein 1;Nrdp1;fetal liver ring finger;neuregulin receptor degradation protein-1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- His
- T7
- DDK
- Myc
- Non
- Avi
- Fc
- GST
Involved Pathway
RNF41 involved in several pathways and played different roles in them. We selected most pathways RNF41 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF41 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB2/ErbB3 signaling events | CHRNE,DOCK7,FMNL3,CHRNA1 |
| Immune System | DEFA6,NLRP3,NOD1,ATG7,AP1M2,HAVCR2,KLHL20,PANX1A,TRIM10,TRIM48 |
| Signal Transduction | UTS2D,JUPA,RDH10,CIT,PYYA,IQGAP3,ARHGAP33,DCLRE1B,FAM13B1,GUCA1E |
| Downregulation of ERBB2:ERBB3 signaling | FMNL3,NRG2A |
| Endocytosis | RAB11BB,AP2M1B,ASAP1,NTRK1,ERBB3,GIT2,FGFR2,PLD1A,SNX6,ADRB2B |
| Class I MHC mediated antigen processing & | RNF220,UBE2E3,RNF144B,TRIM69,TRIM50,LRRC41,MKRN1,LRR1,ERAP1,RNF123 |
| Antigen processing: Ubiquitination & | TRIM9,HECTD3,KLHL20,UBE2V2,HUWE1,ASB2,TRAF7,UFL1,WSB1,STUB1 |
| presentation | RNF6,WWP1,SEC24A,UBE2J2,CMTM2A,RNF34,UBE2U,STUB1,TRIM69,TRIM39 |
| Proteasome degradation | LTN1,TRIM69,STUB1,HUWE1,SPSB4,RBCK1,SPSB2,GAN,LRRC41,TRAF7 |
Protein Function
RNF41 has several biochemical functions, for example, Ral GTPase binding,acid-amino acid ligase activity,erythropoietin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF41 itself. We selected most functions RNF41 had, and list some proteins which have the same functions with RNF41. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tag | SUMO4,SUMO1,SUMO3A,ISG15,SUMO2,SUMO3,UBL5,SUMO2B,NFATC2IP,SUMO3B |
| ubiquitin protein ligase activity | CDC34A,SIAH1,CCNB1IP1,HUWE1,UBR2,RNF175,CBLC,ZNRF1,HERC4,HECTD3 |
| protein binding | COPS2,CDON,UBQLN4,CD24,FOXD3,IL6R,ELN,CABP1,DNASE1,DIS3 |
| erythropoietin receptor binding | EPO |
| ubiquitin-protein transferase activity | HECW2,IRAK1,BIRC2,RNF144AB,UBE2R2,CBLL1,RNF20,TRIM69,LTN1,ANKIB1 |
| zinc ion binding | WHSC1,DTNB,ZRANB1B,ZC3HC1,USP3,TP53I3,MMEL1,ZRANB2,TNFAIP3,LNX2B |
| acid-amino acid ligase activity | RAG1,UBA3,TRIM25 |
| interleukin-3 receptor binding | IL3 |
| Ral GTPase binding | RALBP1,LSM2,MYO1C,USP33,EXOC5,EXOC8,EXOC4,PRKCH,RAB34,PIH1D2 |
Interacting Protein
RNF41 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF41 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF41.
RFC4;TTC1;ARL6IP4;ISCA2;VPS52;LZTS2
Resources
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References
- Roder, K; Werdich, AA; et al. RING Finger Protein RNF207, a Novel Regulator of Cardiac Excitation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:33730-33740(2014).
- Hering, DM; Olenski, K; et al. Genome-wide association study for poor sperm motility in Holstein-Friesian bulls. ANIMAL REPRODUCTION SCIENCE 146:89-97(2014).
