RNF2
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Official Full Name
ring finger protein 2 -
Overview
The polycomb group (PcG) proteins contribute to the maintenance of cell identity, stem cell self-renewal, cell-cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle -
Synonyms
RNF2;ring finger protein 2;E3 ubiquitin-protein ligase RING2;BAP 1;BAP1;DING;HIPI3;RING1B;RING2;protein DinG;RING finger protein 1B;RING finger protein BAP-1;HIP2-interacting protein 3;huntingtin-interacting protein 2-interacting protein 3;B
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- T7
- DDK
- Myc
- Non
- Avi
- Fc
- Flag
Involved Pathway
RNF2 involved in several pathways and played different roles in them. We selected most pathways RNF2 participated on our site, such as Cellular Senescence,Cellular responses to stress,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Post-translational protein modification | MAN1B1,CNIH2,ADAMTS8,SUMF2,DPH1,TRAPPC1,ADAMTS4,TMED2,ARSE,MUC15 |
| Metabolism of proteins | ATP6AP2,DHPS,MTX2,SUMF2,GRPEL2,ZNF408,SFTPB,PHC2,GRP,DOHH |
| SUMOylation | EID3,PHC1,RING1,SAE1,NSMCE4A,NSMCE1,PHC2,SENP1,CBX8,SMC6 |
| SUMO E3 ligases SUMOylate target proteins | PHC2,CBX8,RING1,NSMCE1,NSMCE2,SMC5,PHC3,NSMCE4A,CBX4,SMC6 |
| Oxidative Stress Induced Senescence | PHC3,KDM6B,CBX4,EED,CBX8,CBX8B,RING1,PHC2,BMI1B,SUZ12B |
| SUMOylation of DNA damage response and repair proteins | PHC1,SMC5,NSMCE1,PHC2,SCMH1,NSMCE2,EID3,CBX8,NSMCE4A,SMC6 |
| Cellular Senescence | PHC3,CBX6A,EP400,H1F0,SUZ12A,RING1,CEBPB,HIST3H2BB,PHC1,CBX6 |
| Cellular responses to stress | SCMH1,NUPL2,TINF2,LC3,DNAJC7,EHMT2,C7orf59,HSPA7,HIF1AN,ST13 |
Protein Function
RNF2 has several biochemical functions, for example, RING-like zinc finger domain binding,chromatin binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF2 itself. We selected most functions RNF2 had, and list some proteins which have the same functions with RNF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | AOC3,ABI2,IL32,VPS8,DNMBP,TMUB2,ZFP335,DTNB,PIR,SAMHD1 |
| zinc ion binding | NR1D2B,GLI2,KAT7B,FHL2A,BPTF,BAZ2B,KDM2A,ZDHHC21,PHF20L1,YY1 |
| ubiquitin protein ligase activity | CDC34,RNF220,ARIH2,RNF19A,NEDD4,SIAH2,HECTD1,PJA1,MGRN1,UBE2T |
| contributes_to ubiquitin-protein transferase activity | KLHL18,KLHL24B,BCOR,TCEB1,FBXL3,GAN,KLHL21,KLHL20,KLHL3,KBTBD7 |
| ligase activity | TRIM5,UCHL1,SIAH1A,MID1,MGRN1A,TRIM58,RNF180,TTLL5,RNF5,TRIM2 |
| chromatin binding | TTC5,FLI1,PKN1,POLG,MCMBP,RFX4,HIF1AB,HMGN5,MEOX1,TRIM24 |
| RING-like zinc finger domain binding | UBE2I,BMI1 |
Interacting Protein
RNF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF2.
BMI1;CBX8;PCGF2
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