RCC1

  • Official Full Name

    regulator of chromosome condensation 1

  • Overview

    The Regulator of Chromosome Condensation 1 (RCC1) is a critical cell cycle regulator. This protein is involved in regulating the onset of chromosome condensation during S phase. The RCC1 protein binds to chromatin and interacts with Ran, a nuclear GTP-binding protein. This complex acts as a guanine-nucleotide dissociation stimulator (GDS) by promoting the loss of bound GDP and the uptake of fresh GTP.

  • Synonyms

    RCC1;regulator of chromosome condensation 1;CHC1, chromosome condensation 1;regulator of chromosome condensation;cell cycle regulatory protein;SNHG3-RCC1 readthrough transcript;guanine nucleotide-releasing protein;CHC1;RCC1-I;SNHG3-RCC1;rcc1-a;CHC 1;Chromosome condensation 1;Chromosome condensation protein 1;Guanine nucleotide releasing protein;HERC2;Ran GEF;RanGEF;RCC 1;RCC1 I;RCC1_HUMAN;SHEP1;SNHG3 RCC1;SNHG3 RCC1 readthrough transcript;xrcc1;chc1-a

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • GST
  • Non
  • His
  • Strep
  • Myc&DDK
  • His&Fc&Avi
  • Flag

    Involved Pathway

    RCC1 involved in several pathways and played different roles in them. We selected most pathways RCC1 participated on our site, such as Disease,HIV Infection,HIV Life Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Disease RBP1,IPO5,CCNC,MMAA,CFTR,KREMEN1,MMADHC,TH1L,RLBP1,OPN1MW2
    Late Phase of HIV Life Cycle PDCD6IP,NMT2,TAF1L
    Infectious disease DOCK2,IPO5,PDCD6IP,CHMP4B,NMT2,VPS37A,ANTXR1,PPIAL4A,EEF2,SYT2
    Host Interactions of HIV factors APOBEC3G,AP1B1,PPIAL4A,PSIP1,DOCK2,AP1G1,AP1M2,PACS1,AP1S1
    HIV Life Cycle PDCD6IP,PSIP1,NMT2,PSTPIP2,TAF1L,CHMP4C,NMT1,VPS37A,TCEB3,CHMP4B
    HIV Infection ELL,PDCD6IP,TCEB3,CHMP4C,CDK9,AP1B1,AP1M2,PSTPIP2,AP1G1,NMT2

    Protein Function

    RCC1 has several biochemical functions, for example, Ran guanyl-nucleotide exchange factor activity,chromatin binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCC1 itself. We selected most functions RCC1 had, and list some proteins which have the same functions with RCC1. You can find most of the proteins on our site.

    Function Related Protein
    histone binding NPM2,HIST4H4,CD1D,HIST1H4B,BAZ2A,HIST1H4E,IPO7,HIST1H3I,NFKBIL2,TONSL
    nucleosomal DNA binding HMGN2,HNRNPC,H3F3A,HMGN1,HMGA2,H3F3C,H3F3B,H2AFZ,H2AFY,HMGN4
    chromatin binding PPARG,GLI1,ARID3C,BRD3,PDX1,RDBP,PAX3,FOSL2,HDAC5,SMARCE1
    Ran guanyl-nucleotide exchange factor activity ALS2,RANGRF,RANBP10,RCBTB2,SERGEF
    protein binding NADSYN1,TK1,CLTB,OLFM3,MOBKL2B,EPHB6,FRA10AC1,LAPTM4B,SIX4,ITGB1BP2

    Interacting Protein

    RCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCC1.

    RAN;gdp;Ranbp2;VCAM1;RANBP3;CSNK1A1;gtp

    Resources

    References

    • Rozier, L; Guo, YG; et al. The MRN-CtIP Pathway Is Required for Metaphase Chromosome Alignment. MOLECULAR CELL 49:1097-1107(2013).
    • Ohgami, H; Hiyoshi, M; et al. Xtr, a plural tudor domain-containing protein, is involved in the translational regulation of maternal mRNA during oocyte maturation in Xenopus laevis. DEVELOPMENT GROWTH & DIFFERENTIATION 54:660-671(2012).

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