RBFOX2
-
Official Full Name
RNA binding protein, fox-1 homolog 2 -
Overview
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RBFOX2;RNA binding protein, fox-1 homolog (C. elegans) 2;RBM9, RNA binding motif protein 9;RNA binding protein fox-1 homolog 2;FOX 2;hexaribonucleotide binding protein 2;HNRBP2;HRNBP2;fox-1 homolog B;fox-1 homologue;RNA-binding motif protein 9
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rhesus macaque
- Rat
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
RBFOX2 involved in several pathways and played different roles in them. We selected most pathways RBFOX2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RBFOX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RBFOX2 has several biochemical functions, for example, RNA binding,mRNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBFOX2 itself. We selected most functions RBFOX2 had, and list some proteins which have the same functions with RBFOX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | TRAPPC2,FOS,PAXBP1,AHR,IFI203,CXXC5,CTNNB1,ADD1,HAND1,NAAA |
| protein binding | DDL-2,A1CF,LGALSL,CNST,TXNRD1,SPRR1A,RPL7,EIF2S1,GREM1,HNRNPL |
| transcription corepressor activity | TBL1XR1,WNT4,TDP2,E4F1,BCL11A,ZBTB32,ATF3,HDAC7A,SAP18,TLE2 |
| mRNA binding | C1QBP,RBM8A,XPO5,RBM25,DOM3Z,SRRM4,CPSF5,MRPS7,RPS26,NXF3 |
| nucleotide binding | GNAV1,HRASA,ADCY1A,EEF1A1A,TUBA8L4,BLM,NT5C1A,RBM11,CPEB3,SRSF9 |
| poly(A) RNA binding | RARS2,DIMT1L,EIF4B,KTN1,TSR1,ZRANB2,DDX28,DUS3L,IPO5,RBM14 |
| RNA binding | ZNF638,RBMX,RNASEH2A,CTU1,ATXN1A,RBM39A,DIS3,RTCA,LOC81691,SURF6 |
Interacting Protein
RBFOX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBFOX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBFOX2.
ATXN1;HNRNPF;DAZAP2;QKI
Resources
Related Services
Related Products
References
