RBFOX1
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Official Full Name
RNA binding protein, fox-1 homolog (C. elegans) 1 -
Overview
Fox1, also commonly referred to as Ataxin-2-binding protein 1, is an RNA binding protein involved in the regulation of tissue-specific alternative splicing. This protein contains a highly conserved RRM (RNA recognition motif) and associates with 5'-UGCAUGU-3' elements. This protein has been demonstrated to regulate alternative splicing of tissue specific exons and differentially spliced exons during erythropoiesis. Its alternative name, Ataxin-2-binding protein, is a result of its association with the C terminus of ataxin 2 which may contribute to the pathology of the neurogenerative disease spinocerebellar ataxia type 2 (SCA2). -
Synonyms
RBFOX1;RNA binding protein, fox-1 homolog (C. elegans) 1;RNA binding protein fox-1 homolog 1;fox-1 homolog A;ataxin 2 binding protein 1;ataxin-2-binding protein 1;hexaribonucleotide binding protein 1;A2bp;A2bp1;fox-1;Hrnbp1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E. coli
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- N-GST
- His
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AKR1C4-9534H | Recombinant Human AKR1C4 protein, GST-tagged | E. coli | Human | N-GST | 1-323 aa | |
| AKR7A3-9538H | Recombinant Human AKR7A3 protein, GST-tagged | E. coli | Human | N-GST | 1-331 aa | |
| RBFOX1-13983M | Recombinant Mouse RBFOX1 Protein | Mammalian Cell | Mouse | His |
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| RBFOX1-1437Z | Recombinant Zebrafish RBFOX1 | Mammalian Cell | Zebrafish | His |
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| Rbfox1-7118R | Recombinant Rat Rbfox1 protein, His & T7-tagged | E.coli | Rat | His&T7 | Asp149~Ser399 |
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| RBFOX1-9164HCL | Recombinant Human A2BP1 293 Cell Lysate | HEK293 | Human | Non |
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| Rbfox1-5406M | Recombinant Mouse Rbfox1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| RBFOX1-657H | Recombinant Human RBFOX1 Protein, His-tagged | E.coli | Human | His |
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| RBFOX1-7462M | Recombinant Mouse RBFOX1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RBFOX1-7462M-B | Recombinant Mouse RBFOX1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| RBFOX1-853H | Recombinant Human RBFOX1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
RBFOX1 involved in several pathways and played different roles in them. We selected most pathways RBFOX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RBFOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RBFOX1 has several biochemical functions, for example, RNA binding,mRNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBFOX1 itself. We selected most functions RBFOX1 had, and list some proteins which have the same functions with RBFOX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | CALCOCO1,VPS4A,AXIN1,CDC37,VGLL2,CEP120,NCL,PEX1,ERBB2,PDZD3 |
| protein binding | PPP1R11,DPH2,H3F3C,UBR4,MED30,TSHR,KIF4A,UBQLN4,NSMAF,SMC1A |
| RNA binding | TTC6,RNASEL3,SRSF1B,CNOT7,PPP1R8,RALY,QKIA,RPL30,HBP1,NOL4 |
| mRNA binding | DXO,TYMS,SOSTDC1B,IGF2BP2A,THOC2,RPS3,RPL35,NANOS2,NUDT21,RBMX |
| nucleotide binding | ZRANB3,MRPL23,RBM4.1,CELF5A,RBM24A,SRSF1A,RALYL,ELAVL2,Akap17b,MAP3K12 |
Interacting Protein
RBFOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBFOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBFOX1.
C1orf94;RBPMS;RBFOX2;ATXN1;ATN1;PSMF1;QKI;PLEKHA5;NUMBL
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References
- Utami, KH; Hillmer, AM; et al. Detection of Chromosomal Breakpoints in Patients with Developmental Delay and Speech Disorders. PLOS ONE 9:-(2014).
- Ding, D; Lou, XY; et al. Recurrent Targeted Genes of Hepatitis B Virus in the Liver Cancer Genomes Identified by a Next-Generation Sequencing-Based Approach. PLOS GENETICS 8:-(2012).
