RBBP4
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Official Full Name
retinoblastoma binding protein 4 -
Overview
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] -
Synonyms
RBBP4;retinoblastoma binding protein 4;NURF55;RBAP48;histone-binding protein RBBP4;RBBP-4;CAF-I p48;CAF-1 subunit C;CAF-I 48 kDa subunit;MSI1 protein homolog;retinoblastoma-binding protein 4;retinoblastoma-binding protein p48;chromatin assembly factor 1 subunit C;chromatin assembly factor I p48 subunit;chromatin assembly factor/CAF-1 p48 subunit;nucleosome-remodeling factor subunit RBAP48
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Insect Cells
- Sf9 Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
RBBP4 involved in several pathways and played different roles in them. We selected most pathways RBBP4 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | KDM1B,CHD4A,YEATS4,GATAD2AB,SMARCD1,KANSL3,C17orf81,RBBP5,CCDC101,SAP30 |
| Chromatin organization | MEAF6,MTA2,SUZ12A,KDM4A,KDM3B,KDM5B,SMARCB1A,PHF17,SAP18,CSRP2BP |
| Deposition of new CENPA-containing nucleosomes at the centromere | CENPN,PANE1,CENPP,CENPC1,SMARCA5,CENPQ,HJURP,RBBP7,CENPH,NPM1 |
| Cellular responses to stress | MAP1LC3C,CBX8A,RRAGB,ATG9B,TERF2,PHC1,WIPI1,SUZ12,HSPA14,TXNRD2 |
| Cellular Senescence | POT1,CBX8,RBBP7,UBN1,SUZ12B,CDKN2A,IGFBP7,POT1A,SUZ12A,LMNB1 |
| Chromosome Maintenance | DKC1,PANE1,CENPL,TINF2,CENPA,CENPI,CENPH,CENPP,POLD3,CENPO |
| Cell cycle | MDM2,CSNK2A2,GORASP1,NUPL2,CDKN2C,CUL1,CEP57,SKP1,ORC1L,CDC27 |
| Cell Cycle, Mitotic | CSNK2A2,KIF18A,ODF2,NEDD1,MYBL2,ODF2B,SGOL2,TMEM188,CEP164,STIL |
Protein Function
RBBP4 has several biochemical functions, for example, contributes_to DNA-dependent ATPase activity,contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding,contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBBP4 itself. We selected most functions RBBP4 had, and list some proteins which have the same functions with RBBP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | GATAD2B,SMARCA4,CHD4,ACTB,ACTL6A,MBD3,SMARCE1,MTA2,HDAC2,HDAC1 |
| contributes_to DNA-dependent ATPase activity | GTF2H3,GTF2H4,BPTF,GTF2H2,ERCC3,ERCC2,GTF2H1,MNAT1 |
| histone binding | DNAJC2,ATAD2,SMARCA4A,LEF1,CTCFL,RCC1,NASP,ANP32E,IPO7,COPRS |
| histone deacetylase binding | MAGEA1,PKN1,PRDM1,PARK2,HES1,KLF4,WDTC1,BRMS1,SFPQ,CRY1 |
| protein binding | TAF2,PKMYT1,ATF7,MEI4,MOBP,VEZT,STAT6,HIST2H3C,DAAM1,F10 |
| contributes_to nucleosomal DNA binding | SMARCC2,ACTB,SMARCA4,SMARCC1,ACTL6A,HDAC1,CHD4,GATAD2B,HDAC2,MTA2 |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | ACTL6A,GATAD2B,SMARCE1,SMARCC1,ACTB,SMARCB1,HDAC2,SMARCC2,MBD3,MTA2 |
Interacting Protein
RBBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBBP4.
HDAC1;ZFPM1;HIST1H3D;HAT1;MTA1
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References
- Torres, IO; Kuchenbecker, KM; et al. Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. NATURE COMMUNICATIONS 6:-(2015).
- Xiang, XX; Lan, H; et al. Tuberous Sclerosis Complex 1-Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch. DIABETES 64:519-528(2015).
