RAP1A
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Official Full Name
RAP1A, member of RAS oncogene family -
Overview
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. -
Synonyms
RAP1A;RAP1A, member of RAS oncogene family;ras-related protein Rap-1A;KREV 1;SMGP21;C21KG;G 22K;G-22K;GTP binding protein smg p21A;GTP-binding protein smg p21A;KREV1;OTTHUMP00000013741;RAP 1A;RAP1;RAP1A member of RAS oncogene family;RAP1A_HUMAN;Ras related protein Krev 1;Ras related protein Rap 1A;RAS related protein RAP1A;Ras-related protein Krev-1;OTTHUMP00000013740;RAS-related protein RAP1A;KREV-1
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
RAP1A involved in several pathways and played different roles in them. We selected most pathways RAP1A participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAP1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet activation | GP1BA,MYL12B,F2RL3,GNAS,GNAI1,PIK3R1,ROCK2,PLCB4,PRKACA,ITGA2B |
| Pancreatic secretion | ATP2A3,CCKAR,GNAQ,SLC4A4,CELA2A,CLCA4,CTRL,ATP1B1,PRKCB,ITPR3 |
| Ras signaling pathway | GNG7,PRKCG,PLCE1,FGF18,NRAS,FGF3,MAPK10,PLCG2,PDGFRB,SHC2 |
| Renal cell carcinoma | PIK3CA,PTPN11,PAK7,PIK3CG,MET,PAK2,PIK3R2,VHL,RAF1,ARAF |
| Focal adhesion | TLN2A,PAK7,TESK2,PTK2AA,PTK6,COMP,MYL2,CAV1,EGFRA,PDPK1B |
| Neurotrophin signaling pathway | SHC3,SHC2,SH2B3,IRS1,NFKBIE,SH2B1,ATF4,TRAF6,MAP2K7,NGF |
| cAMP signaling pathway | PAK1,HTR1A,NFKB1,PDE3A,MAPK10,PPP1R12A,MC2R,ATP1B1,ARAP3,LIPE |
| Chemokine signaling pathway | Ccl21a,GNG8,STAT3,LOC100033925,PLCB1,SOS1,PLCB4,CCL6,GNAI2,CCR6 |
| Leukocyte transendothelial migration | ARHGAP5,MYL5,PTK2B,CLDN3,ROCK1,ACTB,VAV1,PRKCG,CLDN17,ITGB2L |
Protein Function
RAP1A has several biochemical functions, for example, GTP binding,GTPase activity,Rap guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAP1A itself. We selected most functions RAP1A had, and list some proteins which have the same functions with RAP1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | ARL8A,NOLC1,TUBA3C,RAB3AA,IFT22,SRP54,IRGE4,GNAI2A,EEF2A.2,PCK2 |
| protein transporter activity | AP1S3B,ZFYVE16,IPO8,USO1,XPO6,TSNAX,C11orf73,KPNA4,IPO5,AP2A1 |
| protein binding | ZFC3H1,MSH5,BTF3,GP1BA,IFI30,RGS14,ATP6V0A4,CCDC123,MTA1,LHFPL5 |
| Ras GTPase binding | CIB1,RAPGEF6,RIN1,RAP1GAP,RGL3,SPHK2,SH3BP4,MAPKAP1,RAPGEF4,RASGRP3 |
| protein complex binding | HNF1B,ITGB1BP1,CDK2,CPD,WASF2,CDK5RAP1,BCAP31,PPP1R9B,CDKN1A,RANBP2 |
| GTPase activity | GSPT1L,GNG10,MFN1,RALBB,EEF2B,GNL3,GNA11A,RAB30,RAB25,EEF2A.1 |
| Rap guanyl-nucleotide exchange factor activity | RAPGEF5,RAPGEF3 |
Interacting Protein
RAP1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAP1A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAP1A.
RASSF5;RAF1;YWHAZ;RAPGEF2;FAS;VHL;Rassf5;RASGRP4;RASSF5;FTSJ1;TRAF6;Rabac1;GANAB;pi3p;gd3
Resources
Research Area
Phospholipases, Small GTPases, and Other Molecules in the Akt PathwayEMT Induction
Mesenchymal to Epithelial Transition
T Cell Migration
Related Services
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References
- Liu, LH; Aerbajinai, W; et al. Radil controls neutrophil adhesion and motility through beta 2-integrin activation. MOLECULAR BIOLOGY OF THE CELL 23:4751-4765(2012).
- Sayyah, J; Bartakova, A; et al. The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17689-17698(2014).
