RAN
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Official Full Name
RAN RAN, member RAS oncogene family -
Overview
Ran (rasrelated nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleuscytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RanGTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedys disease (Xlinked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedys disease. -
Synonyms
RAN;RAN, member RAS oncogene family;GTP-binding nuclear protein Ran;ARA24;Gsp1;TC4;RanGTPase;GTPase Ran;OK/SW-cl.81;ras-like protein TC4;member RAS oncogene family;ras-related nuclear protein;guanosine triphosphatase Ran;androgen receptor-associated protein 24
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Cynomolgus
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
RAN involved in several pathways and played different roles in them. We selected most pathways RAN participated on our site, such as Ribosome biogenesis in eukaryotes,RNA transport,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | FZD9,IL2RB,H2-AA,STAT5A,ETS2,ATF1,POLB,BAX,Fzd4,WNT7B |
| RNA transport | STRAP,RBM8A,THOC3,PABPC5,TGS1,EIF3A,SEH1L,NUP62,EIF3H,EIF3HB |
| Epstein-Barr virus infection | NFKBIE,AKT2,PSMD4,EIF2AK2,VIM,PSMD12,GTF2E1,CD58,PIK3CB,TBK1 |
| Ribosome biogenesis in eukaryotes | IMP4,NHP2L1B,CSNK2A2A,RPP38,EFTUD1,NOP58,cka1,PWP2,NHP2L1,RIOK2 |
Protein Function
RAN has several biochemical functions, for example, GDP binding,GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAN itself. We selected most functions RAN had, and list some proteins which have the same functions with RAN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| androgen receptor binding | KDM4C,KDM3A,TRIM68,PRPF6,BRCA1,NCOA4,PRKCBB,CCNE1,PARK7,FOXH1 |
| importin-alpha family protein binding | GOLGA2,TPX2 |
| dynein intermediate chain binding | HEATR2,HTT,PAFAH1B1 |
| protein binding | TMEM74,FCHSD2,SH3PXD2B,CYBB,SYT7,CORO2B,PCGF3,CBX7,YRDC,MTMR7 |
| chromatin binding | HMGB4,MEOX1,ARID3C,PRKCBB,FANCM,CBX1,NFATC2,CSNK2B,REL,TOX4 |
| GDP binding | RAB11B,RAB7,RAB31,RAB18,RAP2C,SEPT12,ARL3,PIGC,RAB7L1,EIF2B1 |
| contributes_to pre-miRNA binding | TARBP2,DICER1,XPO5 |
| poly(A) RNA binding | MAZ,RPL32,RPS14,ZNF385A,HOXB6,NUFIP2,WDR46,ALG13,HERC5,DYNC1H1 |
| GTP binding | RHOUA,ARF6B,RAB42A,MMAA,GNL3L,EEF1A2,ACSM5,KRAS,RAB1BA,EEF2A.2 |
Interacting Protein
RAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAN here. Most of them are supplied by our site. Hope this information will be useful for your research of RAN.
gdp;RCC1;IPO13
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References
- Gulka, CP; Swartz, JD; et al. Ni(II)NTA AuNPs as a low-resource malarial diagnostic platform for the rapid colorimetric detection of Plasmodium falciparum Histidine-Rich Protein-2. TALANTA 135:94-101(2015).
- Qu, HH; Wang, Y; et al. Development of ELISA for detection of Rh1 and Rg2 and potential method of immunoaffinity chromatography for separation of epimers. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 985:197-205(2015).
