RALGDS
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Official Full Name
ral guanine nucleotide dissociation stimulator -
Overview
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010] -
Synonyms
RALGDS;ral guanine nucleotide dissociation stimulator;RGF;RGDS;RalGEF;ral guanine nucleotide exchange factor
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- GST
- DDK
- Myc
- His
- Non
- Flag
- Avi
- Fc
Involved Pathway
RALGDS involved in several pathways and played different roles in them. We selected most pathways RALGDS participated on our site, such as Ras signaling pathway,Rap signaling pathway,Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RALGDS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | GRIN2A,PRKCG,FGF10,GNG7,FGF7,PLA2G4C,SHC2,PLA2G12B,INS1,GNB4 |
| Colorectal cancer | APPL1,MSH3,PIK3CG,KRAS,AKT2,MSH2,SMAD4,TGFB3,PIK3R1,ARAF |
| Rap signaling pathway | RAPGEF5,FGF12,MAGI1,PIK3R5,IGF1R,FGF1,VEGFA,SIPA1L1,GNAI2,ITGA2B |
| Pancreatic cancer | ERBB2,TGFA,TGFBR2,BRAF,AKT2,RAC3,STAT3,STAT1,TGFB3,TGFBR1 |
| Pathways in cancer | FZD9,COL4A1,FGFR3,MAPK3,BRAF,PTGER3,FAS,WNT7B,TCF7,RASGRP3 |
| Choline metabolism in cancer | MAPK9,TAE1,GRB2,PDGFA,PIK3CB,PIK3R3,PLCG1,TSC1,RPS6KB2,PLA2G4A |
| Phospholipase D signaling pathway | AGPAT5,PLCB2,PIK3CB,KRAS,PIK3R2,INS,PPAP2C,Pdgfa&Pdgfb,PDGFD,MAPK1 |
Protein Function
RALGDS has several biochemical functions, for example, GTPase regulator activity,guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RALGDS itself. We selected most functions RALGDS had, and list some proteins which have the same functions with RALGDS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase regulator activity | RHPN1,RGS12,WASL,DNAJA3,GPSM1B,RIMS1,GPSM2,RGS12B,TSC1,ARL2BP |
| protein binding | ADRB2,C19orf44,WHSC1L1,MUTYH,PDK1,APAF1,KCNE4,HSPA4L,DDC,SH2D1A |
| guanyl-nucleotide exchange factor activity | TBXA2R,RASGRF2B,PCP2,FFAR1,ARHGEF17,VAV3,ARHGEF7,PTGIR,SH2D3C,RASGEF1BA |
Interacting Protein
RALGDS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RALGDS here. Most of them are supplied by our site. Hope this information will be useful for your research of RALGDS.
HRAS;RAP1B;MAPK3;KRAS;CD68;RRAS2;Rit2;RIT1
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References
- Mach, N; Gao, Y; et al. The peripheral blood transcriptome reflects variations in immunity traits in swine: towards the identification of biomarkers. BMC GENOMICS 14:-(2013).
- Samakoglu, S; Deevi, DS; et al. Preclinical Rationale for Combining an EGFR Antibody with Cisplatin/Gemcitabine for the Treatment of NSCLC. CANCER GENOMICS & PROTEOMICS 9:77-92(2012).
