RAG2
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Official Full Name
recombination activating gene 2 -
Overview
his gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. -
Synonyms
RAG2;recombination activating gene 2;V(D)J recombination-activating protein 2;RAG-2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAG2-2162H | Recombinant Human RAG2, GST-tagged | E.coli | Human | GST | C-term-353aa | |
| RAG2-13890M | Recombinant Mouse RAG2 Protein | Mammalian Cells | Mouse | His |
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| RAG2-29371TH | Recombinant Human RAG2 | Wheat Germ | Human | Non | 527 amino acids |
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| RAG2-8961Z | Recombinant Zebrafish RAG2 | Mammalian Cells | Zebrafish | His |
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| RAG2-2547HCL | Recombinant Human RAG2 293 Cell Lysate | HEK293 | Human | Non |
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| RAG2-425HF | Recombinant Full Length Human RAG2 Protein | In Vitro Cell Free System | Human | Full L. 527 amino acids |
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| RAG2-7401M | Recombinant Mouse RAG2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RAG2-7401M-B | Recombinant Mouse RAG2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RAG2 involved in several pathways and played different roles in them. We selected most pathways RAG2 participated on our site, such as FoxO signaling pathway,Primary i,nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| nodeficiency | CD79A,TAP1,DCLRE1C,CD3E,BLNK,UNG,CD3D, Cd79b,TAP2,CD40LG |
| FoxO signaling pathway | GRM1,FOXG1,RBL2,G6PC,IGF1RB,PRMT1,SGK3,HRASA,SOS1,PTEN |
| Primary i | AIRE, Cd79b,CD4,CD8B,CD19,CD79A,TAP2,Cd79a,CD40,AICDA |
Protein Function
RAG2 has several biochemical functions, for example, DNA binding,chromatin binding,methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAG2 itself. We selected most functions RAG2 had, and list some proteins which have the same functions with RAG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | RNF122,TRIM35-30,RNF40,ESR2A,IFIH1,PGLYRP5,TRIM52,RNF4,RNF166,ADAM9 |
| DNA binding | TSHZ3,POU6F1,SIX1,PIAS4,ZFP523,GM239,HER1,TAF13,HOXA5A,RBM6 |
| phosphatidylinositol binding | SNX18A,SEPT12,SNX27B,WDR35,PIK3C2A,SNX1A,ZCCHC2,FES,NISCH,SNX1B |
| phosphatidylinositol-3,4,5-trisphosphate binding | PARD3,COMMD1,RACGAP1,ANXA8,ASAP1,PHLDA3,BTK,GBF1,ZFYVE16,ARHGAP9 |
| chromatin binding | NFKB1,SOX9,ATF5,ERCC6,HDAC3,SP100,CRTC2,BRD3,SKIL,GATA2A |
| ubiquitin protein ligase activity | MSL2,SMURF1,PRPF19,RNF34,PDZRN3B,HECW2,UBE2U,UBR1,TRIM6,RFFL |
| phosphatidylinositol-4,5-bisphosphate binding | STXBP6L,SESTD1,FCHO2,SNX21,FAM21C,SLC9A1,ANXA2,SCIN,ACTN2,MYO1G |
| methylated histone binding | MSL3,PHF19,ATRX,LRWD1,SPIN1,SUZ12,L3MBTL2,KDM4A,ING2,RBBP5 |
| phosphatidylinositol-3,4-bisphosphate binding | ANXA8,D6WSU116E,MAPKAP1,NCF1,AKT1,ADAP2,PLEKHA1,ARAP3,KIF16B,SESTD1 |
Interacting Protein
RAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAG2.
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References
- Rosado, MM; Nasta, F; et al. Effects of GSM-Modulated 900 MHz Radiofrequency Electromagnetic Fields on the Hematopoietic Potential of Mouse Bone Marrow Cells. BIOELECTROMAGNETICS 35:559-567(2014).
- Brodbeck, T; Nehmann, N; et al. Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model. MOLECULAR CANCER 13:-(2014).
