RAF1
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Official Full Name
v-raf-1 murine leukemia viral oncogene homolog 1 -
Overview
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] -
Synonyms
RAF1;v-raf-1 murine leukemia viral oncogene homolog 1;NS5;CRAF;Raf-1;c-Raf;RAF proto-oncogene serine/threonine-protein kinase;Oncogene RAF1;proto-oncogene c-RAF;raf proto-oncogene serine/threonine protein kinase;Craf1;v-Raf;AA990557;BB129353;6430402F14Rik;D830050J10Rik
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- Non
- His
- His&MBP
- DDK&Myc
- Flag&His
- Avi&His
- His&SUMO
- Avi&Fc&His
- GST&His
- Flag
Involved Pathway
RAF1 involved in several pathways and played different roles in them. We selected most pathways RAF1 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | APC,CCNE1,PIM1,Casp3,ABCB1A,WNT3A,SLC7A1,SHC4,MDM2,TNC |
| Alcoholism | HIST1H2BM,HIST1H4I,HIST1H2AL,HIST2H3C2,SHC3,SLC18A1,HIST1H2AB,HIST1H4C,GNAI3,HIST1H2BG |
| B Cell Receptor Signaling Pathway | Cd79a, Cd79b,PLCG2,HDAC5,LAT2,LYN,DOK3,MAP4K1,MAPK3,CDK7 |
| Neurotrophin signaling pathway | SHC3,MAGED1,CAMK2D,CALM1,BAX,RAPGEF1,PIK3R2,MAPK12,PDPK1,RPS6KA6 |
| Influenza A | IFNA1,IRF9,EP300,TNFRSF10A,HSPA1L,PRKCA,SLC25A6,IFNGR2,HLA-DPA1,IL1A |
| Melanogenesis | WNT1,MAP2K2,ASIP,CALM3B,CREB3L3,FZD7,WNT3A,PRKACBB,CALML5,FZD9B |
| Proteoglycans in cancer | GPC3,FZD7,PPP1R12A,WNT6,FZD8,IL12B,FLNA,SMO,MMP2,SOS1 |
| Central carbon metabolism in cancer | PDGFRB,PDGFRA,PIK3CD,PGAM2,PFKP,SLC1A5,SCO2,PIK3R3,HK1,MAPK3 |
| Chemokine signaling pathway | PLCB1,PTK2B,ROCK2,JAK2,PIK3CB,PIK3CG,GRK4,GNAI3,VAV1,PPBP |
Protein Function
RAF1 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAF1 itself. We selected most functions RAF1 had, and list some proteins which have the same functions with RAF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RAB3IL1,ABHD14B,ZNF136,SMARCAD1,MTF1,MSH4,NMB,MACROD1,YWHAH,STBD1 |
| protein kinase activity | NEK12,MAP2K4B,SNRKB,PRKAB1,NEK5,FASTKD5,cka1,GRK7B,CAMK1DB,BMPR1BB |
| protein serine/threonine kinase activity | ATM,TESK1,ADCK4,Aatk,IKBKB,AKT3,OBSCN,PAK6,CDC42BPG,PAK4 |
| NOT small GTPase binding | BRAF |
| protein heterodimerization activity | H2AFV,MYO5A,MAFGA,ADORA1,HIST1H2BI,PVRL1,MID2,TCF4,FLOT1,ANO9A |
| MAP kinase kinase kinase activity | MAP3K13,STK4,MAP3K4,TAOK2,MAP3K5,MAP3K8,MAP3K15,MAP3K14,STK3,YSK4 |
| metal ion binding | CYP4T8,KDM2AA,RNF44,ZNF512,DNAJA2,ZBTB8A,AGAP2,TRIM35-20,CAT,IDS |
| mitogen-activated protein kinase kinase binding | MAPK8IP3,ACE,TRIB3,MAP3K11,TRIB1,TAOK2,DLG1,TRIB2,ARRB1,BRAF |
| ATP binding | MSH4,MAT2AL,WNK1,LIMK1A,UBE2Q2,UBA6,PIM3,PASK,MCCC1,IKBKAP |
Interacting Protein
RAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAF1.
HRAS;YWHAZ
RAF1 Related Signal Pathway
Resources
Research Area
Cancer Drug TargetsIntracellular Kinases in the Akt Pathway
ROS and Stress Resistance
MAP3K
Intracellular Signaling Molecules in Angiogenesis
C-type Lectin Receptors
Oncoprotein-Signal Transducers
RAS-MAPK Pathway
Related Services
Related Products
References
- Feiz, L; Williams-Carrier, R; et al. A protein with an inactive pterin-4a-carbinolamine dehydratase domain is required for Rubisco biogenesis in plants. PLANT JOURNAL 80:862-869(2014).
- Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).
