RAB4A
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Official Full Name
RAB4A, member RAS oncogene family -
Overview
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] -
Synonyms
RAB4A;RAB4A, member RAS oncogene family;RAB4;HRES1;HRES-1;HRES-1/RAB4;ras-related protein Rab-4A;HTLV-1 related endogenous sequence
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- T7
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
RAB4A involved in several pathways and played different roles in them. We selected most pathways RAB4A participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | BF2,CYTH1A,CXCR1,CCDC53,ADRB3A,KITA,D6WSU116E,EHD2,VPS26B,ERBB4 |
Protein Function
RAB4A has several biochemical functions, for example, ATPase activator activity,ATPase binding,GDP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB4A itself. We selected most functions RAB4A had, and list some proteins which have the same functions with RAB4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GDP binding | KRAS,ARF1,RAB8B,GNAI1,IIGP1,EIF2B1,RALB,RAB7A,PRPS2,RHOA |
| ionotropic glutamate receptor binding | DLG1L,IL1R1,CACNG2,GNAS,DLG1,DLG3,SHANK1,SHANK3,ADRB2,DLG4B |
| protein binding | ESR1,S100A7,NCOA5,STXBP3A,LGI4,RAPGEF4,DYX1C1,KLKB1,AGFG1,RGS17 |
| ATPase activator activity | AHSA1L,DNAJB6,TOR1AIP1,AHSA2,TOR1AIP2,DNAJC19,DNAJC10,ATP1B2,DNAJB1,AHSA1 |
| ATPase binding | NR1H2,ESR1,USP25,ATPIF1A,ATP6V0A1A,DERL1,FBL,TOR1AIP2,RALB,UBXN1 |
| GTPase activity | ARF6,GTPBP3,RRAGC,GNB5,RAB5B,RAB39A,RAB6C,RAB43,GTPBP1L,RAB1A |
| GTP binding | ATL3,GPN2,ARL4C,SEPT9A,RHOD,ARL17B,DNAJC27,RAB23,RAB5C,RND3B |
| protein transporter activity | DPY19L2,ARFGAP3,AP1S3B,XPO5,AP2S1,KPNA2,VPS26A,AP1S3A,AP1S1,IPO5 |
| syntaxin binding | STX6,SCFD1,SNAP47,NAPGA,SYT5B,SYT17,VPS52,NAPAB,DOC2B,STX10 |
Interacting Protein
RAB4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB4A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB4A.
GDI1;gtp;EXOC5;VPS52;GDI2;PASK;APBB3;SOD2;TP53;IDH3A;PTTG1IP
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