PXN
-
Official Full Name
paxillin -
Overview
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the;extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been;described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well;as physiological properties (PMID:9054445). -
Synonyms
PXN;paxillin;FLJ16691
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- His
- S
- Trx
- T7
- Non
- DDK
- Myc
- GST
- Avi
- Fc
Involved Pathway
PXN involved in several pathways and played different roles in them. We selected most pathways PXN participated on our site, such as Chemokine signaling pathway,VEGF signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | ITGA2,FGF1B,FGF6A,MYL10,PIP4K2A,SCIN,PIP5KL1,PTK2AA,PIP4K2AA,PIP5K1BB |
| Leukocyte transendothelial migration | PRKCG,PTK2,CLDN14,PIK3CB,RAP1B,RAC1,RASSF5,MYLPF,PTK2B,F11R |
| Viral carcinogenesis | STAT5B,HIST2H4A,PRKACB,HIST1H4F,MAPKAPK2,MDM2,HIST1H2BP,PIK3R2,ACTN3,RBL1 |
| Focal adhesion | FN1A,MYL2B,RAC3,RAP1A,RHOB,HGF,PIK3R2,TNW,ITGA8,RAC3A |
| VEGF signaling pathway | PIK3CB,MAPK13,PRKCA,PIK3CA,PPP3CCA,PIK3R5,PLA2G4C,PIK3R3B,PPP3CCB,CASP9 |
| Chemokine signaling pathway | GSK3A,NCF1,PRKCB,VAV3,SHC1,SHC2,IKBKB,GRK5,PLCB4,VAV1 |
| Proteoglycans in cancer | ESR1,FZD8,MAP2K1,PLAU,SMAD2,GAB1,HGF,MDM2,AKT2,PIK3R3 |
| Bacterial invasion of epithelial cells | VCL,SEPT2,SEPT12,SEPT6,ELMO1,GAB1,CDH1,SEPT1,PTK2,CTNNA3 |
Protein Function
PXN has several biochemical functions, for example, BH4 domain binding,beta-catenin binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PXN itself. We selected most functions PXN had, and list some proteins which have the same functions with PXN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| vinculin binding | DAG1,C22orf28,ACTN1,TLN1,CTNNA1,DMD,NRAP,SYNM,SORBS3 |
| beta-catenin binding | KDM6B,ESR1,DACT1,TCF7,LZIC,CDH2,CARM1,RORA,APC2,TAX1BP3 |
| protein binding | LIPT2,NOG,EXOC4,ERP44,RNF13,CDK18,DNAJC15,CTTNBP2NL,TNIP3,MYCN |
| zinc ion binding | DTNBA,MLL1,ZDHHC15B,NR6A1,KLF7,TIMM13,CRIP1,NR2C1,LMO7B,ZDHHC19 |
| integrin binding | CTGFB,NOV,ITGA3,ICAM3,COL3A1,JAM3,ACTN1,ITGB1BP2,SRC,THY1 |
| protein kinase binding | TOM1L1,PRKRIP1,PFKFB2,RPS6KA3,PTPN23,CSPG4,TPX2,STK11IP,ADCY6,DVL1 |
Interacting Protein
PXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PXN here. Most of them are supplied by our site. Hope this information will be useful for your research of PXN.
PTK2;PTPN11;Sorbs1
PXN Related Signal Pathway
Resources
Research Area
Adaptor ProteinsAdaptor Proteins in the Akt Pathway
Adherens Junction Proteins in Endothelial Cells
Focal Adhesion Proteins in Endothelial Cells
Adherens Junction Proteins in VSMC
Focal Adhesion Proteins in VSMC
Intracellular Signaling Molecules in Angiogenesis
Focal Adhesion Adaptor and Scaffold Proteins
Invadopodia Molecules
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References
