PUS1
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Official Full Name
pseudouridine synthase 1 -
Overview
This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure o -
Synonyms
PUS1;pseudouridine synthase 1;tRNA pseudouridine synthase A, mitochondrial;A730013B20Rik;DOBI;MGC112655;MGC11268;MLASA;mPus1p;Pseudouridylate synthase 1;tRNA pseudouridine(38-40) synthase;tRNA pseudouridylate synthase I;tRNA uridine isomerase I;tRNA-uridine isomerase I;TRUA_HUMAN;OTTMUSP00000027965;OTTMUSP00000027966;OTTMUSP00000027967;OTTMUSP00000027968;MPUS1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- His&T7
- Non
- Myc&DDK
- Flag
Involved Pathway
PUS1 involved in several pathways and played different roles in them. We selected most pathways PUS1 participated on our site, such as Gene Expression,tRNA modification in the nucleus and cytosol,tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with PUS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | ZNF613,SUPT16H,TAF1D,ZNF212,D1BWG0212E,SSRP1,KRBA1,ZNF354B,ZNF10,ZKSCAN3 |
| tRNA modification in the nucleus and cytosol | ALKBH8,TRMT5,QTRTD1,METTL1,TRMT11,CDKAL1,OSGEP,TRMT61A,TRMT12,KIAA1456 |
| tRNA processing | TSEN15,CCDC76,TPRKB,XPOT,TRMT11,FAM98B,RPP14,ADAT3,C22orf28,LCMT2 |
Protein Function
PUS1 has several biochemical functions, for example, ligand-dependent nuclear receptor transcription coactivator activity,poly(A) RNA binding,pseudouridine synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PUS1 itself. We selected most functions PUS1 had, and list some proteins which have the same functions with PUS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligand-dependent nuclear receptor transcription coactivator activity | MED17,MED30,ACTN1,CALCOCO1,SLC30A9,THRAP3,TADA3,ZCCHC12,ACTN4,RBM14 |
| poly(A) RNA binding | CDK13,EXOSC9,TCP1,GNL3,NOC4L,RIMS1,SF3A2,RBM3,PURA,PIGC |
| pseudouridine synthase activity | RPUSD4,DKC1,PUS10,RPUSD2,TRUB2,PUS7,RPUSD3,PUSL1,RPUSD1,PUS7L |
Interacting Protein
PUS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PUS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PUS1.
ere_dna;ICT1
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References
- Bykhovskaya, Y; Mengesha, E; et al. Pleiotropic effects and compensation mechanisms determine tissue specificity in mitochondrial myopathy and sideroblastic anemia (MLASA). MOLECULAR GENETICS AND METABOLISM 91:148-156(2007).
- Fernandez-Vizarra, E; Berardinelli, A; et al. Nonsense mutation in pseudouridylate synthase 1 (PUS1) in two brothers affected by myopathy, lactic acidosis and sideroblastic anaemia (MLASA). JOURNAL OF MEDICAL GENETICS 44:173-180(2007).
