PURA
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Official Full Name
purine-rich element binding protein A -
Overview
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008] -
Synonyms
PURA;purine-rich element binding protein A;PUR1;PURALPHA;PUR-ALPHA;transcriptional activator protein Pur-alpha;purine-rich single-stranded DNA-binding protein alpha
Recombinant Proteins
- Human
- Bacillus subtilis
- Mouse
- Zebrafish
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- Non
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PURA-2071H | Recombinant Human PURA, His-tagged | E.coli | Human | His | 1-322aa | |
| PURA-0357B | Recombinant Bacillus subtilis PURA protein, His-tagged | E.Coli/Yeast | Bacillus subtilis | His |
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| PURA-13722M | Recombinant Mouse PURA Protein | Mammalian Cells | Mouse | His |
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| PURA-255Z | Recombinant Zebrafish PURA | Mammalian Cells | Zebrafish | His |
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| PURA-31263TH | Recombinant Human PURA | Wheat Germ | Human | Non | 51 amino acids |
|
| PURA-31266TH | Recombinant Human PURA | Wheat Germ | Human | Non | 110 amino acids |
|
| PURA-30154H | Recombinant Human PURA protein, GST-tagged | E.coli | Human | GST | Met1-Asp322 |
|
| PURA-6117H | Recombinant Human PURA Protein (Met1-Asp322), N-His tagged | E.coli | Human | His | Met1-Asp322 |
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| PURA-7301M | Recombinant Mouse PURA Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PURA-7301M-B | Recombinant Mouse PURA Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PURA involved in several pathways and played different roles in them. We selected most pathways PURA participated on our site, such as Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with PURA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diurnally regulated genes with circadian orthologs | QK,STBD1,ZFR,DAZAP2,CRY2,CRY1,QKI,AZIN1,UCP3,CEBPB |
Protein Function
PURA has several biochemical functions, for example, SMAD binding,double-stranded telomeric DNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PURA itself. We selected most functions PURA had, and list some proteins which have the same functions with PURA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| purine-rich negative regulatory element binding | ELK3 |
| double-stranded telomeric DNA binding | TERFA,TERF1,TERF2 |
| transcription factor binding | TBX5,LEF1,DACT2,IFI203,KAT8,STK4,KDM1A,CREBBP,PIAS2,HMGB1 |
| translation repressor activity, nucleic acid binding | PAIP2B,CPEB3,CPEB4,CPEB2,CPEB1,CELF4,CPEB1A,CPEB1B,PPP1R2P9,CELF1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | PDX1,ATF1,TLE4,CEBPA,NFATC1,HNF1B,NKX2-5,HNF4A,IRF8,MITF |
| poly(A) RNA binding | SMG1,DDX39B,ADK,PPP1R2P9,LRPPRC,TFAM,HMGN2,RBM34,NCOA5,RPL5A |
| SMAD binding | RNF111,ACVR1B,TGFBR1,TGFBR2,SKILB,TCF12,FKBP1A,MAGI2,TOB1,SKOR1A |
| protein binding | MIEN1,ENOX1,PRCC,SCAMP2,LMX1B,HSPA8,NUDCD3,TBX15,NFKBIB,RC3H2 |
| single-stranded DNA binding | TSNAX,RPA3,CSDA,HMGB2,CNBPA,MCM7,ERCC4,FUBP1,TDP1,SSBP2 |
Interacting Protein
PURA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PURA here. Most of them are supplied by our site. Hope this information will be useful for your research of PURA.
lt_sv40;lt_povjc;RB1;rb_cerae_protein;CNBP;EIF2AK2;GABARAPL2;SNW1;q8te30_human;ESR2
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References
- Li, J; Mo, ZL; et al. Generation and evaluation of virulence attenuated mutants of Edwardsiella tarda as vaccine candidates to combat edwardsiellosis in flounder (Paralichthys olivaceus). FISH & SHELLFISH IMMUNOLOGY 43:175-180(2015).
- Kobayashi, Y; Suzuki, K; et al. C9orf10 protein, a novel protein component of Pur alpha-containing mRNA-protein particles (Pur alpha-mRNPs): Characterization of developmental and regional expressions in the mouse brain. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 56:723-731(2008).
