PTPRZ1
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Official Full Name
protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -
Overview
DSD-1 reacts with a glycosaminoglycan epitope selectively expressed on radial gliacytes of which a subpopulation shows stem cell properties. Cells isolated with this antibody from embryonic mouse tissue had multipotent characteristics and could turn into neurons, astrocytes and oligodendrocytes. The epitope is highly conserved and has been found in several vertebrates. -
Synonyms
PTPRZ1;protein tyrosine phosphatase, receptor-type, Z polypeptide 1;PTPRZ, PTPZ;receptor-type tyrosine-protein phosphatase zeta;phosphacan;PTP18;RPTPB;R-PTP-zeta-2;receptor-type tyrosine phosphatase beta/zeta;protein-tyrosine phosphatase receptor type Z polypeptide 2;protein tyrosine phosphatase, receptor-type, zeta polypeptide 1;PTPZ;HPTPZ;PTPRZ;HPTPzeta;PTP-ZETA;RPTPbeta
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Yeast
- HEK293
- GST
- His
- His&T7
- His&Fc&Avi
- His&SUMO
Involved Pathway
PTPRZ1 involved in several pathways and played different roles in them. We selected most pathways PTPRZ1 participated on our site, such as Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRZ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spinal Cord Injury | GDNF,KLK8,NOX4,RTN4R,LGALS3,MBP,LILRB3,AIF1,TNFSF13B,RTN4 |
Protein Function
PTPRZ1 has several biochemical functions, for example, fibroblast growth factor binding,hydrolase activity,phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRZ1 itself. We selected most functions PTPRZ1 had, and list some proteins which have the same functions with PTPRZ1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphoprotein phosphatase activity | MTM1,CDC14A,PPM1NB,PTPN2B,DUSP26,PTPRDB,PTPN11,PPM1AB,SSH2,PTEN |
| protein tyrosine phosphatase activity | PALD1B,PTP4A1,DUSP19,MTMR1A,EYA4,PTPN6,PTPRNA,DUSP10,DUSP13,PTPRA |
| phosphatase activity | CTDNEP1B,DUSP22A,PTPN11A,PTPRNA,MINPP1A,ACPL2,PPP1CB,DUSP19B,SACM1LA,SSH2B |
| fibroblast growth factor binding | FGFR3,GLG1B,FGFR1A,FIBPA,FGFRL1,KLB,RPS2,FGFBP1,FGFR2,GPC1 |
| protein binding | CDC42BPA,GOLPH3,ADI1,BIRC3,KDR,TPRKB,CRELD2,PRKCB,TICAM2,IFT88 |
| hydrolase activity | C6AST3,ACP5A,DDX3,KLK13,ABHD15,ATP2B3A,KLK1B22,Chil3,CAPN1B,GZME |
Interacting Protein
PTPRZ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRZ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRZ1.
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References
- Wang, V; Davis, DA; et al. Characterization of the Activation of Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) by Hypoxia Inducible Factor-2 Alpha. PLOS ONE 5:-(2010).
- Adrien, D; Ludger, KH; et al. Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. LANGENBECKS ARCHIVES OF SURGERY 395:261-275(2010).
