PTK7
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Official Full Name
PTK7 protein tyrosine kinase 7 -
Overview
Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. -
Synonyms
PTK7;PTK7 protein tyrosine kinase 7;inactive tyrosine-protein kinase 7;CCK4;CCK-4;colon carcinoma kinase 4;colon carcinoma kinase-4;protein-tyrosine kinase 7;tyrosine-protein kinase-like 7;pseudo tyrosine kinase receptor 7
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rhesus macaque
- Rat
- Cynomolgus/Rhesus macaque
- Rabbit
- Cynomolgus/Rhesus
- Cynomolgus
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Yeast
- Human cells
- His and Myc
- GST
- His
- Non
- His&Flag
- Flag
- Fc
- His&Avi
- His&SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PTK7 involved in several pathways and played different roles in them. We selected most pathways PTK7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PTK7 has several biochemical functions, for example, ATP binding,protein binding,protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK7 itself. We selected most functions PTK7 had, and list some proteins which have the same functions with PTK7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine kinase activity | DSTYK,IGF1R,PTK7A,ZNF143B,ERBB2,HCK,MAP2K6,WEE2,ZAP70,LCK |
| protein binding | PCSK9,Ctsl,MTERF,ZNF155,DACH1,C11orf46,KRTAP9-4,PIP5K1C,FGD5,PDLIM3 |
| ATP binding | YME1L1B,SRC,EPHB1,MTHFD1B,SMC6,TEX14,GSK3AB,STK30,RAD51L1,GK5 |
Interacting Protein
PTK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK7.
CTNNB1;CLNK;prfA;wnt3a
Resources
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References
- Gartner, S; Gunesch, A; et al. PTK 7 Is a Transforming Gene and Prognostic Marker for Breast Cancer and Nodal Metastasis Involvement. PLOS ONE 9:-(2014).
- Zhao, WA; Cui, CH; et al. Bioinspired multivalent DNA network for capture and release of cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:19626-19631(2012).
