PTGR1
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Official Full Name
prostaglandin reductase 1 -
Overview
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. -
Synonyms
PTGR1;prostaglandin reductase 1;leukotriene B4 12 hydroxydehydrogenase , LTB4DH;ZADH3;zinc binding alcohol dehydrogenase domain containing 3;PRG-1;15-oxoprostaglandin 13-reductase;leukotriene B4 12-hydroxydehydrogenase;NADP-dependent leukotriene B
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PTGR1 involved in several pathways and played different roles in them. We selected most pathways PTGR1 participated on our site, such as Arachidonic acid metabolism,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | CYP2Y3,PTGS1,CYP2U1,PTGDSA,PTGES3B,AWAT1,CYP4F3,CYP2E1,PLA2G4C,PLA2G10 |
| Synthesis of Lipoxins (LX) | ALOX5B.2,ALOX5B.3 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | PTGDSA,FAM213B |
| Metabolism of lipids and lipoproteins | FAAH2B,ARSJ,LMF2,CYP2R1,INSIG1,GRHL1,GLTPD1,FABP1B.1,LBR,COQ7 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | DPEP2,ALOX5AP,DPEP1,ALOX5B.3,ALOX5B.2 |
| sphingosine and sphingosine-1-phosphate metabolism | ACER1 |
| Metabolism | COX14,NHLRC1,FABP11A,PEMT,FIG4,NUDT3B,CYP2D6,DHCR7,FABP1B.1,ITPA |
Protein Function
PTGR1 has several biochemical functions, for example, 13-prostaglandin reductase activity,15-oxoprostaglandin 13-oxidase activity,2-alkenal reductase [NAD(P)] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGR1 itself. We selected most functions PTGR1 had, and list some proteins which have the same functions with PTGR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 13-prostaglandin reductase activity | PTGR2 |
| 15-oxoprostaglandin 13-oxidase activity | PTGR2 |
| zinc ion binding | ADAM20,PPARAA,PIAS1,SH3RF3,RSPRY1,ZDHHC4,HLTF,RNF31,KDM4A,RNF113A |
Interacting Protein
PTGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGR1.
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References
- Zhao, RJ; Pan, ZY; et al. Stimulation of non-neuronal muscarinic receptors enhances chemerin/ChemR23 system in dysfunctional endothelial cells. LIFE SCIENCES 92:10-16(2013).
- Naidansuren, P; Park, CW; et al. Molecular characterization of bovine placental and ovarian 20 alpha-hydroxysteroid dehydrogenase. REPRODUCTION 142:723-731(2011).
