PTEN
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Official Full Name
phosphatase and tensin homolog -
Overview
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008] -
Synonyms
PTEN;phosphatase and tensin homolog;BZS;DEC;CWS1;GLM2;MHAM;TEP1;MMAC1;PTEN1;10q23del;phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;phosphatase and tensin-like protein;mutated in multiple advanced cancers 1;MMAC1 phosphatase and tensin homolog deleted on chromosome 10;phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Sf21 Cells
- Mammalian Cells
- Insect Cells
- Sf9 Cells
- HEK293
- GST
- His
- Non
- Flag
- Avi&Fc&His
- DDK&Myc
Involved Pathway
PTEN involved in several pathways and played different roles in them. We selected most pathways PTEN participated on our site, such as Inositol phosphate metabolism,FoxO signaling pathway,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | Il2,Gh,FLT1,KRAS,PKN2,IGF1R,IFNB1,FGF9,FGF8,IL2RG |
| Tight junction | GNAI3,CLDN15,CDC42,CLDN5A,JAM3B,MYHC4,CLDN22,ASH1L,MAGI2,VAPAL |
| mTOR signaling pathway | PIK3R3A,PIK3R3B,TSC1,RPS6KA3,RPS6KB2,PIK3R2,INSB,STK11,DDIT4,ULK3 |
| Small cell lung cancer | ITGAV,TRAF5,PIK3CA,IKBKG,TRP53,PTK2,NFKB1,CKS2,TRAF2,RXRG |
| Prostate Cancer | PDGFC,PIK3CG,AKT2,TCF7L2,IKBKB,CREB3L1,SMARCD1,HSP90AB1,SPRY1,TCF7 |
| Phosphatidylinositol signaling system | ITPKB,CALM3A,PIK3R5,PIP5K1A,ITPK1A,CDS1,IMPA2,TMEM55A,PLCD4,PIK3R3A |
| Sphingolipid signaling pathway | FCER1G,FCER1A,PPP2R5D,LASS4,BAX,PRKCA,MAP2K1,ROCK2,ASAH2,SGMS1 |
| Glioma | PIK3R1,PIK3R5,AKT1,PLCG2,CALML5,CAMK2A,PLCG1,IGF1R,SHC1,TP53 |
| Focal adhesion | AKT3A,PTK6,VASP,COL4A2,PIK3R5,RAC1,RHOA,BIRC3,PDPK1,COL6A1 |
Protein Function
PTEN has several biochemical functions, for example, PDZ domain binding,anaphase-promoting complex binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTEN itself. We selected most functions PTEN had, and list some proteins which have the same functions with PTEN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| anaphase-promoting complex binding | PLK1,CLSPN |
| lipid binding | FAM123B,LTC4S,Alb,BPIFB1,APOL4,PTGS1,LPAR3,DNM1L,RUFY1,DBIL5 |
| phosphoprotein phosphatase activity | PPM1DA,DUSP22A,CDC14AA,PTPRZ1,PPP3CCB,PTPRFB,PPTC7A,TIMM50,CTDSPL2A,PPM1AB |
| platelet-derived growth factor receptor binding | PDGFB,ITGA5,PDGFA,Pdgfa&Pdgfb,PDGFC,PDGFRB,PTPRJ,IL1R1,TYMP,LYN |
| protein kinase binding | BCL2L14,IKBKB,PRDX3,HDAC7,EEF1A2,AXIN2,RPS6,LAT,GRB2,MAPK6 |
| protein tyrosine/serine/threonine phosphatase activity | DUSP19A,CDC14C,DUSP22B,PTPRQ,TENC1,LRP8,SSH1,CDC14AB,SACM1LB,SACM1LA |
| PDZ domain binding | KIDINS220,TGFBR3,ATP2B4,DLG4,BAIAP2,DLC,NKD1,NLGN1,GRIK2,PLEKHA1 |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | PTENB,PTENA |
| identical protein binding | GOT1,CD28,CLDN2,SH2B2,TRIM5,CUBN,PRDX3,CRYAB,ALDH4A1,RUVBL2 |
Interacting Protein
PTEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTEN here. Most of them are supplied by our site. Hope this information will be useful for your research of PTEN.
SLC9A3R1;PDGFRB;FRK;SLC9A3R2
PTEN Related Signal Pathway
Resources
Research Area
Cancer Drug TargetsTumor Suppressors
Phosphatases and Regulators
Phosphatases in the Akt Pathway
Growth Hormone/IGF-I Axis
Hematopoietic Stem Cell Markers
Intracellular Signaling Molecules in Angiogenesis
Breast Cancer Stem Cell Markers
Apical-basal Polarity Effectors
T Follicular Helper (Tfh) Cells
Glioma Biomarkers
Ovarian Cancer Biomarkers
PI3K Pathway
Related Services
Related Products
References
- Collaud, S; Tischler, V; et al. Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC CANCER 15:-(2015).
- Ritprajak, P; Azuma, M; et al. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. ORAL ONCOLOGY 51:221-228(2015).
