PSME3
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Official Full Name
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified. -
Synonyms
PSME3;proteasome (prosome, macropain) activator subunit 3 (PA28 gamma;Ki);proteasome activator complex subunit 3;Ki;PA28 gamma;PA28G;REG GAMMA;11S regulator complex gamma subunit;11S regulator complex subunit gamma;Activator of multicatalytic protease subunit 3;Ki antigen;Ki nuclear autoantigen;Ki, PA28 gamma;PA28gamma;Proteasome (prosome, macropain) activator subunit 3;Proteasome activator 28 gamma;Proteasome activator 28 subunit gamma;Proteasome activator subunit 3;PSME3_HUMAN;REG-gamma;proteasome activator 28-gamma;activator of multicatalytic prot;PA28-gamma
Recombinant Proteins
- Human
- Mouse
- Chicken
- Cynomolgus
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
PSME3 involved in several pathways and played different roles in them. We selected most pathways PSME3 participated on our site, such as APC/C-mediated degradation of cell cycle proteins,APC/C:Cdc20 mediated degradation of Securin,APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSME3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | PSMA8,AURKB,ANAPC10,PSMD10,PSMD5,PSMD9,PSMD14,UBE2C |
| APC/C:Cdc20 mediated degradation of Securin | PSMA8,PSMD9,ANAPC10,UBE2C,PSMD10,PSMD5,PSMD14 |
| ARMS-mediated activation | KBTBD7,DUSP5,PAQR3A,NRG2A,EGF,EGFR,PSMD14,HBEGF,DUSP7,DUSP2 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | PSMA8,PSMD9,ANAPC10,PSMD5,PSMD14,NEK2,PSMD10,UBE2C |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | PSMD14,PSMD5,PSMA8,ANAPC10,PSMD9,PSMD10,UBE2C,NEK2 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | PSMD14,PSMD10,EIF4G1,PSMD9,HNRNPD,PSMD5,PSMA8 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | PSMA8,PSMD9,UBE2C,ANAPC10,PSMD14,PSMD5,PSMD10,NEK2 |
| APC/C-mediated degradation of cell cycle proteins | UBE2C,CDK2,NEK2,AURKB,PSMA8,PSMD10,PSMD14,PSMD9,PSMD5,ANAPC10 |
Protein Function
PSME3 has several biochemical functions, for example, MDM2/MDM4 family protein binding,endopeptidase activator activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSME3 itself. We selected most functions PSME3 had, and list some proteins which have the same functions with PSME3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| p53 binding | PLK3,TP73,ZNF385A,RNF34,NTRK3,RFFL,TAF1,EP300,MAPKAPK5,TRIM29 |
| protein binding | GNE,XPO5,SHKBP1,SUPV3L1,ZFPL1,RPS11,ATP5F1,TRIM24,BAK1,PFDN5 |
| endopeptidase activator activity | PSME2,SFRP2,ADRM1,PSMD14,PSME1 |
| identical protein binding | DIAPH1,SHARPIN,PDCD6,ACTB,DNMT3A,KCNH2,STK4,CRYAA,PDGFB,BCHE |
| MDM2/MDM4 family protein binding | CDK5RAP3,TRP53,CDKN2A,PPARA,CAV1,RFWD3 |
Interacting Protein
PSME3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSME3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSME3.
ZCCHC10;EAF1;BBS2;MDM2
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