PSEN2
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Official Full Name
presenilin 2 (Alzheimer disease 4) -
Overview
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. -
Synonyms
PSEN2;AD4;PS2;AD3L;AD3LP;STM2;CMD1V;presenilin 2 (Alzheimer disease 4);presenilin 2;presenilin-2;AD5;E5-1;PS-2;STM-2;OTTHUMP00000035671;OTTHUMP00000035672;OTTHUMP00000228286;OTTHUMP00000228288;EC 3.4.23.-;EC 3.4.23;PSNL2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- E. coli
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PSEN2 involved in several pathways and played different roles in them. We selected most pathways PSEN2 participated on our site, such as Notch signaling pathway,Neurotrophin signaling pathway,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSEN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotrophin signaling pathway | NTF3,ARHGDIB,CAMK2B,MAP2K2,MAPK3,PSEN1,SHC1,MAP3K3,NFKBIE,NTF4 |
| Notch signaling pathway | PTCRA,JAG1A,DLC,YY1,CTBP2,DVL3A,MFNG,RBPJ,CIR1,DNER |
| Alzheimers disease | NDUFV1,BACE2,NDUFV2,NDUFS4,LRP1,UQCR11,COX7B2,CALM2,TNF,FADD |
Protein Function
PSEN2 has several biochemical functions, for example, aspartic-type endopeptidase activity,endopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSEN2 itself. We selected most functions PSEN2 had, and list some proteins which have the same functions with PSEN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | PSMB10,ADAMTS3,SENP5,ADAM10,SENP3B,PSMA3,KLK1B11,PCSK6,MMP1A,Ren1 |
| aspartic-type endopeptidase activity | PSEN1,CTSE,CNTNAP5A,SPPL2,PIP,NRIP2,ASPRV1,PGA5,BACE1,PGA4 |
| protein binding | DOK4,USE1,MEX3C,C22orf28,PDIA6,TLE1,SH3GL3,PIN1,RAD21,F3 |
Interacting Protein
PSEN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSEN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSEN2.
FHL2;CIB1;UBQLN1;SRI;BCL2L1;ECSIT;FLNB
PSEN2 Related Signal Pathway
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