PSCA
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Official Full Name
prostate stem cell antigen -
Overview
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. -
Synonyms
PSCA;prostate stem cell antigen;PRO232
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Human Cells
- Yeast
- GST
- His
- Fc
- Non
- Avi&His
- Flag
Involved Pathway
PSCA involved in several pathways and played different roles in them. We selected most pathways PSCA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PSCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PSCA has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PSCA itself. We selected most functions PSCA had, and list some proteins which have the same functions with PSCA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
PSCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSCA here. Most of them are supplied by our site. Hope this information will be useful for your research of PSCA.
Resources
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References
- Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
- Knowles, SM; Tavare, R; et al. Applications of ImmunoPET: Using I-124-Anti-PSCA A11 Minibody for Imaging Disease Progression and Response to Therapy in Mouse Xenograft Models of Prostate Cancer. CLINICAL CANCER RESEARCH 20:6367-6378(2014).
