PRPF19
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Official Full Name
pre-mRNA processing factor 19 -
Overview
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008] -
Synonyms
PRPF19;pre-mRNA processing factor 19;PSO4;SNEV;PRP19;UBOX4;hPSO4;NMP200;pre-mRNA-processing factor 19;PRP19/PSO4 homolog;senescence evasion factor;nuclear matrix protein 200;PRP19/PSO4 pre-mRNA processing factor 19 homolog;nuclear matrix protein NMP200 related to splicing factor PRP19
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- Sf9 Cells
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PRPF19 involved in several pathways and played different roles in them. We selected most pathways PRPF19 participated on our site, such as Spliceosome,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | SRSF7B,SRSF3,SRSF5A,SF3A3,LSM6,SRSF2,PPIL1,SNRPF,HSPA1L,SNRPA |
| Ubiquitin mediated proteolysis | SKP2,FBXW11A,UBE2IA,CUL1,RHOBTB1,TRIM32,HERC3,CUL5,FZR1,UBE2NA |
Protein Function
PRPF19 has several biochemical functions, for example, identical protein binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF19 itself. We selected most functions PRPF19 had, and list some proteins which have the same functions with PRPF19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | HERC5,MED23,RNF144AB,TRIM2,HECTD2,COP1,RAG1,CBLL1,SIAH1,CMTM2A |
| ligase activity | TTC3,FPGS,CBLB,TRIM37,TRIM21,TRAIP,NSMCE2,NSMCE1,UFL1,TTLL6 |
| identical protein binding | TP73,TP53,ACADM,CBY1,APOE,CLDN11,HCN2,PYDC3,G6PD,COL1A1 |
| ubiquitin-ubiquitin ligase activity | UBE2K,ANAPC11,UBE4B,AMFR,STUB1,UBOX5,PPIL2,RBX1 |
| protein binding | RNF34,CEP120,EMD,MAP1B,EIF4E2,RD3,POLE4,GAB1,NR2C2AP,FRAG1 |
Interacting Protein
PRPF19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF19 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF19.
RBM5;YWHAG;CDC5L;Snw1;CDC40;BCAS2;RBM10
Resources
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References
- RaffalliMathieu, F; Geneste, O; et al. Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA - Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene. EUROPEAN JOURNAL OF BIOCHEMISTRY 245:17-24(1997).
- IZAURRALDE, E; LEWIS, J; et al. A CAP-BINDING PROTEIN COMPLEX MEDIATING U SNRNA EXPORT. NATURE 376:709-712(1995).
- ZHANG, GH; TANEJA, KL; et al. LOCALIZATION OF PRE-MESSENGER-RNA SPLICING IN MAMMALIAN NUCLEI. NATURE 372:809-812(1994).
