PRKG1
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Official Full Name
protein kinase, cGMP-dependent, type I -
Overview
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. -
Synonyms
PRKG1;protein kinase, cGMP-dependent, type I;PRKG1B, PRKGR1B;cGMP-dependent protein kinase 1;PGK;PKG;protein kinase, cGMP-dependent, regulatory, type I, beta;1;cGK;cGK1;cGKI;cGK 1;PRKG1B;PRKGR1B;cGKI-BETA;cGKI-alpha;FLJ36117;MGC71944;DKF
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- Insect Cells
- Sf9 Cells
- HEK293
- Sf21 Cells
- E.coli
- His
- Non
- GST
- Avi&Fc&His
- Flag
- DDK&Myc
- His&Myc
Involved Pathway
PRKG1 involved in several pathways and played different roles in them. We selected most pathways PRKG1 participated on our site, such as cGMP-PKG signaling pathway,Vascular smooth muscle contraction,Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gap junction | TUBA8,PDGFD,CX35B,GUCY1B3,PRKACAB,HTR2A,PDGFC,ADRB3B,MAP2K2A,PRKG2 |
| Circadian entrainment | GRIA4,RYR2,GNG3,GNG7,GNAO1,KCNJ6,GNB3,KCNJ5,GNGT2,PRKCB |
| cGMP-PKG signaling pathway | MEF2D,PIK3CG,CREB3L1,ATF4,ATP2B1,Adcy4,CALM2,KCNMB4,PPP3CA,ATP1A4 |
| Salivary secretion | PMAP-36,BST1,STATH,LPO,GNAS,DMBT1,GUCY1B3,ATP1B4,VAMP2,LYZ1 |
| Regulation of lipolysis in adipocytes | PIK3R2,GNAI3,PIK3CB,AKT2,Adcy4,PRKACB,GNAI1,TSHR,PTGS2,PIK3R5 |
| Vascular smooth muscle contraction | PPP1CAA,KCNMB2,ADORA2AA,KCNMB3,PPP1CA,GNA13A,PRKCB,PPP1R14AB,RHOAA,PLA2G10 |
| Olfactory transduction | OLFR998,OR10H1,OLFR507,OLFR13,SLC8A1,OR2K2,OLFR11,SLC24A4,OLFR147,OLFR18 |
| Long-term depression | MAP2K1,GNAI1,MAPK1,KRAS,PRKG2,GNAI3,GNAO1,HRAS,MAP2K2,PLCB3 |
| Platelet activation | GNAI1,SYK,PLA2G4D,GUCY1A3,MYL12B,PTGIR,MAPK13,MAPK11,ITPR1,AKT2 |
Protein Function
PRKG1 has several biochemical functions, for example, ATP binding,cGMP binding,cGMP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKG1 itself. We selected most functions PRKG1 had, and list some proteins which have the same functions with PRKG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | UBD,LIMK2,GLI2,NPHP1,MNAT1,DOLK,VPS26A,SPINK2,ZCCHC11,RPRD1B |
| cGMP binding | PDE5A,PRKG1A,PDE6G,CNGA5,PRKG2,PDE10A,CNGA4,CNGA1,PDE6C,CNGA3 |
| calcium channel regulator activity | CACNA2D1,CACNA2D3,GRM2A,SGK2B,HPCAL4,NRXN2,GRM2,SGK3,CACNA2D2,PLN |
| cGMP-dependent protein kinase activity | PRKG1A,PRKG2 |
| ATP binding | CKBA,ABCB5,IGF1RA,CDK14,CDK20,ATAD2B,KALRN,PAK2A,MCM5,ETNK1 |
Interacting Protein
PRKG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKG1.
ZNF646;LMO2;FAM124A;BMPR2;Gkap1;3',5'-cyclic gmp;SMAD4;2_aha_camp;8-aha-camp;8-aha-omethyladenosine
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References
- Zhang, L; Lukowski, R; et al. Thrombocytosis as a Response to High Interleukin-6 Levels in cGMP-Dependent Protein Kinase I Mutant Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 33:1820-1828(2013).
- Zhang, FX; Liu, XJ; et al. Inhibition of Inflammatory Pain by Activating B-Type Natriuretic Peptide Signal Pathway in Nociceptive Sensory Neurons. JOURNAL OF NEUROSCIENCE 30:10927-10938(2010).
