PRKAR1B
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Official Full Name
protein kinase, cAMP-dependent, regulatory, type I, beta -
Overview
Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.[supplied by OMIM, Jun 2009] -
Synonyms
PRKAR1B;protein kinase, cAMP-dependent, regulatory, type I, beta;PRKAR1;cAMP-dependent protein kinase type I-beta regulatory subunit
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PRKAR1B involved in several pathways and played different roles in them. We selected most pathways PRKAR1B participated on our site, such as Apoptosis,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | PRKAA2,CALM3B,RPS6KB1B,MAP2K2B,PRKAG2,PRKAG3,CBLC,GYS1,EIF4E1C,GRB2A |
| Apoptosis | ATM,PRKAR1A,PIK3R3A,TNFSF10,DBNLB,PIK3R3B,CASP12,IL1B,IRF2,PPP3R1 |
Protein Function
PRKAR1B has several biochemical functions, for example, cAMP binding,cAMP-dependent protein kinase inhibitor activity,cAMP-dependent protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAR1B itself. We selected most functions PRKAR1B had, and list some proteins which have the same functions with PRKAR1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cAMP-dependent protein kinase regulator activity | PRKAG2,PRKAR2A,PRKAR1AB,PRKAR2AB,PRKAR2B,PRKAR1A,CXCL10,PRKAG1,PRKAR1AA,PRKAR2AA |
| cAMP-dependent protein kinase inhibitor activity | PKIA,PRKAR2B,PRKAG2,PRKAR1A,PKIG,PKIB,PRKAR2A |
| protein kinase A catalytic subunit binding | GSK3A,PJA2,EZR,CSK,PRKAR1A,SOX9,GSK3B,KCNQ1,PRKAR2B,PKIA |
| cAMP binding | RAPGEF3,PDE3A,HCN2,PRKAR2B,POPDC2,PDE10A,BVES,PDE11A,PDE4A,HCN4 |
Interacting Protein
PRKAR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAR1B.
PRKACA;kemptide;Dlg4;EGFR;UBE2I;hmuV;manB
Resources
Research Area
Apoptosis Intracellular KinasesIntracellular Kinases in the Akt Pathway
ROS and Stress Resistance
PKA Isoforms
Related Services
Related Products
References
- Loza-Huerta, A; Vera-Estrella, R; et al. Certain Strongylocentrotus purpuratus sperm mitochondrial proteins co-purify with low density detergent-insoluble membranes and are PKA or PKC-substrates possibly involved in sperm motility regulation. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1830:5305-5315(2013).
- Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
