PPY
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Official Full Name
pancreatic polypeptide -
Overview
Human Pancreatic Polypeptide (PP or Pancreatic hormone) is synthesized by neuroendocrine cells in the pancreas and is found in enteric nerves. Its release is stimulated during all phases of digestion and increases gastric acid secretion and motility in the stomach and intestine. PP has been shown to suppress appetite. Mice and men with overweight have relatively low levels of PP in contrast to anorexics, which have increased levels of PP. Transgenic mice with an over expression of PP showed reduced food intake, which was reversed by administration of PP antiserum. PP consists of 36 amino acids and has a molecular weight of 4391 Da. -
Synonyms
PPY;pancreatic polypeptide;pancreatic prohormone;PP;pancreatic polypeptide Y;PNP;Obinepitide;Pancreatic prohormone;Pancreatic polypeptide Y;PP;Pancreatic Polypeptide;Pancreatic hormone
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Mammalian Cell
- HEK293
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
PPY involved in several pathways and played different roles in them. We selected most pathways PPY participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR ligand binding | OPN1LW,NPFFR2,LPAR5A,CRHB,RGR,KISS1,AMCF-II,GPBAR1,FFAR3,GPRC6A |
| Signaling by GPCR | OR10A5,XK,CXCR7B,GPR4,OPN4A,OR7D2,PROKR1,RAMP3,NMBA,EMR3 |
| Class A/1 (Rhodopsin-like receptors) | RXFP2,PENKB,OPN5,NPFF,GPR65,CCL19A.2,SSTR4,RLN3A,GPR37B,LPAR5A |
| G alpha (i) signalling events | CHRM2,CXCL13,LPAR2A,FPR-RS3,PMCH,PYY,OPN1SW,RLN3,LPAR1,SSTR1 |
| Signal Transduction | NRP2,ASH2L,ACVR1C,NMU,GAS8,SST,TRIM33,NPFF,OPHN1,SST1.1 |
| Peptide ligand-binding receptors | RLN3A,QRFP,GPR37L1,KEL,PROKR1A,PNOCB,PYY,NMBB,PENK,INSL5 |
| GPCR downstream signaling | TRPC7,GPBAR1,DRD2,CXCR6,OXGR1A.1,ADM2A,RGS12,CCR9,LPAR2B,SSTR1 |
Protein Function
PPY has several biochemical functions, for example, G-protein coupled receptor binding,hormone activity,neuropeptide hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPY itself. We selected most functions PPY had, and list some proteins which have the same functions with PPY. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor binding | GNAT3,GNA15,PACRG,HAND2,GNAI2B,NPB,RSPO4,CORT,SAA1,ARHGEF12 |
| neuropeptide hormone activity | VIP,CALCB,NPPA,NPY,QRFP,ADCYAP1,PNOC,GRP,GAL,CRH |
| hormone activity | GH2,SST2,INS1,PYYA,TSHB,SST6,PTHLH,GAST,GCGB,NPPC |
| receptor binding | ASIP,Fgf15,GSTK1,MAP7,FRK,EDN3,PECI,EPB49,JAK2,IDH1 |
Interacting Protein
PPY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPY here. Most of them are supplied by our site. Hope this information will be useful for your research of PPY.
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References
- Wang, D; Hu, WH; et al. Multifunctionalized reduced graphene oxide-doped polypyrrole/pyrrolepropylic acid nanocomposite impedimetric immunosensor to ultra-sensitively detect small molecular aflatoxin B-1. BIOSENSORS & BIOELECTRONICS 63:185-189(2015).
- Babakhanian, A; Ehzari, H; et al. A novel modified electrode as GC/PPy-AuNPs-rGO/L-Cys/Ag@MUA nanostructure configuration for determination of CCP and CRP antibodies in human blood serum samples. BIOSENSORS & BIOELECTRONICS 63:490-498(2015).
