PPP2CB
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Official Full Name
protein phosphatase 2, catalytic subunit, beta isozyme -
Overview
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. -
Synonyms
PPP2CB;protein phosphatase 2, catalytic subunit, beta isozyme;protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform;serine/threonine-protein phosphatase 2A catalytic subunit beta isoform;PP2Abeta;protein phosphatase 2A catalytic subunit;beta isoform;PP2A beta;PP2A-beta;PP2AB_HUMAN;PP2CB;Protein phosphatase 2 catalytic subunit beta isozyme;Protein phosphatase 2, catalytic subunit, beta isoform;Protein phosphatase 2A catalytic subunit beta isoform;Protein phosphatase type 2A catalytic subunit;Serine/threonine protein phosphatase 2A catalytic subunit beta;OTTHUMP00000225455;protein phosphatase 2A catalytic subunit, beta isoform;serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rhesus macaque
- Rat
- Chicken
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
PPP2CB involved in several pathways and played different roles in them. We selected most pathways PPP2CB participated on our site, such as mRNA surveillance pathway,Sphingolipid signaling pathway,Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Long-term depression | MAP2K1,HRAS,GNAO1,IGF1R,MAP2K2,GRID2,ITPR1,PRKCB,GNA11,PPP2CA |
| Oocyte meiosis | MAP2K1,CALM3,SMC1B,IGF1R,REC8B,PPP1CAA,CPEB1B,PRKACG,SMC1A,MAD2L1 |
| Dopaminergic synapse | DRD1,DRD2,PPP2R3C,COMT,GNB3,CREB3L1,GNB2,PPP2R1A,GNG12,PRKCB |
| Chagas disease (American trypanosomiasis) | GNAL,MAPK13,PPP2R1A,GNAQ,CD247,CALR,CCL2,PPP2R2B,PIK3R2,TGFB1 |
| Tight junction | AKT2,CLDNJ,SYMPK,LLGL1,OCLNB,PPP2R2BB,CLDN5A,PRKCBA,JAM3B,PPP2R2D |
| TGF-beta signaling pathway | LFT2,ROCK2B,BMP4,SMAD3A,NOG3,BMP6,CUL1B,GDF6,LFT1,NBL1 |
| mRNA surveillance pathway | PPP1CC,CPSF3,PPP2R2BB,DDX39B,PPP2R3A,RBM8A,PABPN1L,PELO,PPP2R2B,PABPN1 |
| Adrenergic signaling in cardiomyocytes | TNNC1,CALM1,ADCY2B,PPP1CBL,CACNB2A,CACNG8,ATP1B3A,ATP1B3B,AKT2L,SLC9A1 |
| Sphingolipid signaling pathway | FCER1G,RAC2,PRKCA,PPP2R5B,PLD2,SGPP1,GAB2,SPHK2,MAP3K5,GNA12 |
Protein Function
PPP2CB has several biochemical functions, for example, metal ion binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2CB itself. We selected most functions PPP2CB had, and list some proteins which have the same functions with PPP2CB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | JAK2,TFCP2,ERCC1,MYO1C,VIM,MAP3K7,SDC1,PXK,PPP1R9B,EP300 |
| contributes_to protein serine/threonine phosphatase activity | CYCS |
| protein binding | HIST1H4K,SPSB2,ZFP57,RAB11FIP3,NHLRC1,MEIS1,RBM6,PDE6H,MED8,PUF60 |
| metal ion binding | ZFP503,CYP2AA8,ACVR2AA,PARP12A,ZFP526,ZNF576,ASAP1,OLA1,ZNF71,ZNF280B |
Interacting Protein
PPP2CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2CB.
PPP2R1A;IGBP1;AXIN2;TCP1;CCT6A
Resources
Research Area
FGF FamilyReceptor Tyrosine Kinases (RTKs) in the Akt Pathway
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
Glial Lineage Markers
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References
