PPP1R8
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Official Full Name
protein phosphatase 1, regulatory subunit 8 -
Overview
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. -
Synonyms
PPP1R8;protein phosphatase 1, regulatory subunit 8;protein phosphatase 1, regulatory (inhibitor) subunit 8;nuclear inhibitor of protein phosphatase 1;activator of RNA decay;ard 1;ARD1;NIPP 1;NIPP1;nuclear subunit of PP 1;PRO2047;protein phospha
Recombinant Proteins
- Chicken
- Human
- Rhesus macaque
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
PPP1R8 involved in several pathways and played different roles in them. We selected most pathways PPP1R8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PPP1R8 has several biochemical functions, for example, DNA binding,RNA binding,endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R8 itself. We selected most functions PPP1R8 had, and list some proteins which have the same functions with PPP1R8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | RPS4Y1,FAM103A1,RBM8A,CSTF3,DIMT1,ASCC1,SRSF1A,CTU1,DDX51,IFIT8 |
| protein binding | TNFRSF13B,VEGFC,OTULIN,LOXL2,RTKN,SERPINF1,ZNF433,MEN1,PTCRA,HSPB1 |
| DNA binding | HER9,ZNF703,CERS2,RYBPB,TCEB3B,ZFAND5B,MBD3,HMGA1B,FOSB,FLYWCH1 |
| protein phosphatase type 1 regulator activity | PHACTR1,PPP1R15A,UBXN2B,UBXN2A,KCNS1,PHACTR3,PPP1R7,PHACTR3A,PHACTR4B,NSFL1C |
| protein serine/threonine phosphatase inhibitor activity | PPP1R17,PPP1R14C,PPP1R1A,PPP1R1C,PPP1R11 |
| endonuclease activity | RSFR,SMG6,PMS2,SETMAR,MRE11A,DNASE2A,EAR1,RNASEL2,FEN1,NTHL1 |
Interacting Protein
PPP1R8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R8.
PPP1CA;PPP1CB;APPBP2;PPP1CC;CDC5L;LRRK2;NME2;SF3A2;Cep72;STC2;GBP2;CRMP1;SETDB1
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References
- Lengyel, I; Nichol, KA; et al. Characterization of protein kinase and phosphatase systems in chick ciliary ganglion. NEUROSCIENCE 70:577-588(1996).
- Klein, AL; Berkaw, MN; et al. O-Linked N-Acetylglucosamine Modification of Insulin Receptor Substrate-1 Occurs in Close Proximity to Multiple SH2 Domain Binding Motifs. MOLECULAR & CELLULAR PROTEOMICS 8:2733-2745(2009).
- Lindenthal, C; Klinkert, MQ; et al. Identification and biochemical characterisation of a Protein Phosphatase 5 homologue from Plasmodium falciparum. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 120:257-268(2002).
- Pfitzer, G; Sonntag-Bensch, D; et al. Thiophosphorylation-induced Ca2+ sensitization of guinea-pig ileum contractility is not mediated by Rho-associated kinase. JOURNAL OF PHYSIOLOGY-LONDON 533:651-664(2001).
