PPM1D
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Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1D -
Overview
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] -
Synonyms
PPM1D;protein phosphatase, Mg2+/Mn2+ dependent, 1D;WIP1;PP2C-DELTA;protein phosphatase 1D;protein phosphatase Wip1;wild-type p53-induced phosphatase 1;protein phosphatase 2C delta isoform;protein phosphatase 1D magnesium-dependent, delta isoform
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- His&Fc&Avi
- Myc&DDK
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPM1D-2917H | Recombinant Human PPM1D protein, His-tagged | E.coli | Human | His | 254-423 aa | |
| PPM1D-3553R | Recombinant Rhesus monkey PPM1D Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PPM1D-1744H | Recombinant Human PPM1D Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PPM1D-1744H-B | Recombinant Human PPM1D Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| PPM1D-2668H | Recombinant Human PPM1D Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| PPM1D-324HFL | Recombinant Full Length Human PPM1D Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| PPM1D-3371R | Recombinant Rhesus Macaque PPM1D Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PPM1D-3371R-B | Recombinant Rhesus Macaque PPM1D Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Ppm1d-5046M | Recombinant Mouse Ppm1d Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
PPM1D involved in several pathways and played different roles in them. We selected most pathways PPM1D participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PPM1D has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1D itself. We selected most functions PPM1D had, and list some proteins which have the same functions with PPM1D. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
PPM1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1D here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1D.
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