POFUT2
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Official Full Name
protein O-fucosyltransferase 2 -
Overview
Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 (PubMed 16464857)). -
Synonyms
POFUT2;protein O-fucosyltransferase 2;C21orf80, chromosome 21 open reading frame 80;GDP-fucose protein O-fucosyltransferase 2;FUT13;KIAA0958;O-FucT-2;peptide-O-fucosyltransferase 2;C21orf80
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POFUT2-1825H | Recombinant Human POFUT2, GST-tagged | E.coli | Human | GST | 21-429aa | |
| POFUT2-27511TH | Recombinant Human POFUT2, His-tagged | E.coli | Human | His | 196-429 a.a. |
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| POFUT2-285H | Recombinant Human POFUT2 protein, GST-tagged | Wheat Germ | Human | GST | 1-429 a.a. |
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| POFUT2-3892H | Recombinant Human POFUT2 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| POFUT2-4816Z | Recombinant Zebrafish POFUT2 | Mammalian Cells | Zebrafish | His |
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| POFUT2-3056HCL | Recombinant Human POFUT2 293 Cell Lysate | HEK293 | Human | Non |
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| Pofut2-4979M | Recombinant Mouse Pofut2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| POFUT2-606HF | Recombinant Full Length Human POFUT2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 429 amino acids |
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| POFUT2-6576HFL | Recombinant Full Length Human POFUT2 protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| POFUT2-903H | Recombinant Human POFUT2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
POFUT2 involved in several pathways and played different roles in them. We selected most pathways POFUT2 participated on our site, such as Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with POFUT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other types of O-glycan biosynthesis | FUT9A,GXYLT1,POFUT1,RFNG,B3GALTLB,B4GALT1,POMT1,ST6GAL2,POMT2,POMGNT1 |
Protein Function
POFUT2 has several biochemical functions, for example, peptide-O-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POFUT2 itself. We selected most functions POFUT2 had, and list some proteins which have the same functions with POFUT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide-O-fucosyltransferase activity | POFUT1 |
Interacting Protein
POFUT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POFUT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POFUT2.
USP22;GABARAP;MAP1LC3A
Resources
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References
- Muller, J; Rana, NA; et al. O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function. PLOS ONE 9:-(2014).
- Vasudevan, D; Takeuchi, H; et al. Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism. CURRENT BIOLOGY 25:286-295(2015).
