PODXL
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Official Full Name
podocalyxin-like -
Overview
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. -
Synonyms
PODXL;podocalyxin-like;podocalyxin;Gp200;PC;PCLP;GCTM-2 antigen;podocalyxin-like protein 1;PCLP-1;MGC138240
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Chicken
- E.coli
- HEK293
- Mammalian Cells
- Insect Cells
- Yeast
- GST
- His
- DDK&Myc
- Flag&His
- GST&His
- His&T7
- Non
- Avi&Fc&His
Involved Pathway
PODXL involved in several pathways and played different roles in them. We selected most pathways PODXL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PODXL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PODXL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PODXL itself. We selected most functions PODXL had, and list some proteins which have the same functions with PODXL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CLPB,C2orf57,DTD2,RBL1,YWHAB,PPP3CB,KIF14,ROR2,TOP1,DNAI2 |
Interacting Protein
PODXL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PODXL here. Most of them are supplied by our site. Hope this information will be useful for your research of PODXL.
IQGAP1
Resources
Research Area
Endothelial Cell Development MoleculesEndothelial Cell Markers
Hemangioblast Markers
Germ Cell Markers
Hematopoietic Stem Cell Markers
Embryonic and Induced Pluripotent Stem Cell Markers
Mesodermal Lineage Markers
Apical Molecules
Related Services
Related Products
References
- Kaprio, T; Hagstrom, J; et al. A comparative study of two PODXL antibodies in 840 colorectal cancer patients. BMC CANCER 14:-(2014).
- Kaprio, T; Fermer, C; et al. Podocalyxin is a marker of poor prognosis in colorectal cancer. BMC CANCER 14:-(2014).
