PNPO
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Official Full Name
pyridoxamine 5-phosphate oxidase -
Overview
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. -
Synonyms
PNPO;pyridoxamine 5-phosphate oxidase;pyridoxine 5 phosphate oxidase;pyridoxine-5-phosphate oxidase;PDXPO;EC 1.4.3.5;FLJ10535;PNPO_HUMAN;Pyridoxal 5 phosphate synthase;pyridoxamine 5 phosphate oxidase;Pyridoxamine phosphate oxidase;Pyridoxamine-phosphate oxidase;pyridoxal 5-phosphate synthase;pyridoxine 5-phosphate oxidase
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Mouse
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PNPO involved in several pathways and played different roles in them. We selected most pathways PNPO participated on our site, such as Vitamin B metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | UGT2A3,HLCS,DGAT2,TKTB,NSDHL,IMPA2,MDH1AA,GLULB,CYP2C37,ACAT2 |
| Vitamin B metabolism | AOX1,AOX3,PHOSPHO2,PDXKB,PDXKA,AOX4,PDXK,PDXP,PSAT1,AOX2P |
Protein Function
PNPO has several biochemical functions, for example, FMN binding,pyridoxamine-phosphate oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPO itself. We selected most functions PNPO had, and list some proteins which have the same functions with PNPO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FMN binding | CREG2,DHODH,NOS1,NOS2A,CREG1,TYW1B,NOS3,HAO1,HAO2,NOS2B |
Interacting Protein
PNPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPO here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPO.
MYO1C;Junb
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