PLA2G10
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Official Full Name
phospholipase A2, group X -
Overview
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipi -
Synonyms
PLA2G10;phospholipase A2, group X;group 10 secretory phospholipase A2;GXPLA2;Group X secretory phospholipase A2;GXSPLA2;Phosphatidylcholine 2 acylhydrolase GX;Phospholipase A2 group X;SPLA2;sPLA2X;sPLA2-X;GX sPLA2;OTTHUMP00000045725;phosphatidylcholine 2-acylhydrolase 10
Recombinant Proteins
- Rat
- Human
- Chicken
- Mouse
- Mammalian Cells
- HEK293
- E.coli
- Human Cells
- Insect Cells
- His
- Fc
- Non
- Flag
- DDK
- Myc
- Avi
- GST
Involved Pathway
PLA2G10 involved in several pathways and played different roles in them. We selected most pathways PLA2G10 participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vascular smooth muscle contraction | PLA2G2D,MYH11,PTGIR,ADCY1A,CACNA1DA,CALM4,PPP1R12A,PRKACAA,NPR1A,KCNMB4 |
| Ras signaling pathway | MAPK1,INS1,PLA1A,RAC2,FGF19,GNG2,GNGT2,MAP2K1,TEK,CALM1 |
| Metabolic pathways | SDHDA,CHKA,MT-ND1,ST3GAL6,ALDH1B1,ATP6V1B1,MPI,LASS5,FUT2,UQCRH |
| Ether lipid metabolism | PLA2G4AA,LPCAT4,PLD1,EPT1,PLA2G5,PPAP2CB,PAFAH1B1,PAFAH2,PLA2G16,PLA2G4B |
| Pancreatic secretion | SLC4A4,AMY2B,PLA2G2A,PLA2G12A,ATP2B1,AMY2A,PLA2G2D,ATP2A3,CPA2,PLCB2 |
| Linoleic acid metabolism | CYP2P7,CYP2C70,PLA2G5,PLA2G2E,PLB1,CYP3A25,PLA2G4F,CYP2C9,CYP2C19,PLA2G12A |
| Arachidonic acid metabolism | CYP2P7,FAAH2,ALOX12E,CYP4F22,FAAH2B,GPX6,CBR2,CBR1L,CYP2P10,CYP4F14 |
| Glycerophospholipid metabolism | STIL,PLA2G4A,MBOAT7,LYCAT,GPD2,PLA2G16,AGPAT6,PCYT1BB,TESCA,LPIN2 |
| Fat digestion and absorption | ABCG8,LIPF,PLA2G2D,PLA2G1B,PLA2G5,PPAP2C,PNLIPRP1,MOGAT2,SCARB1,FABP1 |
Protein Function
PLA2G10 has several biochemical functions, for example, calcium ion binding,phospholipase A2 activity,phospholipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G10 itself. We selected most functions PLA2G10 had, and list some proteins which have the same functions with PLA2G10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipase activity | PNLIPRP2,LIPM,Cel,ABHD6,DAGLB,LIPC,LIPN,LIPH,PLA2G4AA,LIPI |
| phospholipase A2 activity | PLA2G6,PRDX6,PLB1,PLA2G2A,PLA2G4A,PLA2G4D,LCAT,PLA2G2D,PLA2G4AA,PLA2G1B |
| calcium ion binding | FREM2,JAG2,PCDHA4,CDHR1,SGCA,PLCH2,GUCA1A,S100A12,ITPR3,TNNC1 |
Interacting Protein
PLA2G10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G10.
MYO10
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References
- Sin, BA; Akdis, M; et al. T-cell and antibody responses to phospholipase A(2) from different species show distinct cross-reactivity patterns. ALLERGY 66:1513-1521(2011).
- Shaposhnik, Z; Wang, X; et al. The synergistic inhibition of atherogenesis in apoE(-/-) mice between pravastatin and the sPLA(2) inhibitor varespladib (A-002). JOURNAL OF LIPID RESEARCH 50:623-629(2009).
