PIP5K1A

  • Official Full Name

    phosphatidylinositol-4-phosphate 5-kinase, type I, alpha

  • Overview

    Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. Contributes to the activation of PLD2.

  • Synonyms

    PIP5K1A;phosphatidylinositol-4-phosphate 5-kinase, type I, alpha;phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;PIP5KIalpha;PIP5K1-alpha;ptdIns(4)P-5-kinase 1 alpha;68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Sf9 Cells
  • Insect Cells
  • Sf21 Cells
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PIP5K1A-1727H Recombinant Human PIP5K1A, GST-tagged E.coli Human GST 151-500aa
PIP5K1A-3532H Recombinant Human PIP5K1A protein, His-tagged E.coli Human His 151-500 aa
PIP5K1A-1460H Active Recombinant Human PIP5K1A, GST-tagged Sf9 Cells Human GST Full length
PIP5K1A-170H Active Recombinant Human PIP5K1A protein, GST-tagged Insect Cells Human GST
PIP5K1A-4821HF Active Recombinant Full Length Human PIP5K1A Protein, GST-tagged Sf21 Cells Human GST Full L. 1-549(end)
PIP5K1A-1082H Recombinant Human Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, GST-tagged Sf9 Cells Human GST
PIP5K1A-12828M Recombinant Mouse PIP5K1A Protein Mammalian Cells Mouse His
PIP5K1A-3893C Recombinant Chicken PIP5K1A Mammalian Cells Chicken His
PIP5K1A-3173HCL Recombinant Human PIP5K1A 293 Cell Lysate HEK293 Human Non
PIP5K1A-6755M Recombinant Mouse PIP5K1A Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PIP5K1A-6755M-B Recombinant Mouse PIP5K1A Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PIP5K1A involved in several pathways and played different roles in them. We selected most pathways PIP5K1A participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIP5K1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fc gamma R-mediated phagocytosis RAC1,PPAP2C,PIK3CA,SYK,PRKCD,LAT,ASAP2,VAV1,LYN,LIMK1
    Choline metabolism in cancer MAP2K1,PCYT1A,PLA2G4C,DGKQ,DGKZ,PPAP2A,NRAS,WASF3,GRB2,SLC22A3
    Endocytosis HRASB,ARPC3,IQSEC1,FAM21A,STAMBPB,PARD6GB,ADRB3,SMAP2,EHD3,PIP5K1B
    Inositol phosphate metabolism ITPKC,PLCD1B,PIP4K2A,MTMR6,PIP5K1B,PIP5K2,PIP5KL1,PLCD4,IPMKB,PI4KA
    Metabolic pathways PSAT1,HSD3B1,POLR2C,GALNT7,MAT2B,NDUFB7,CYP2C39,PPT1,AKR1B1L,SI
    Regulation of Actin Cytoskeleton FGFR2,ARHGEF6,VIL1,NCKAP1L,ABI2,FGF18A,CD14,MAPK6,PIP4K2B,PFN3
    Phospholipase D signaling pathway DNM3,GNA12,AVP,CXCR1,Pdgfa&Pdgfb,RHEB,ARF6,KIT,PIP5K1C,NRAS
    Phosphatidylinositol signaling system CALM4,CALM,INPP5A,DGKAA,PIK3CD,IMPA2,PLCB4,CALM2B,INPP5D,PLCB1

    Protein Function

    PIP5K1A has several biochemical functions, for example, 1-phosphatidylinositol-4-phosphate 5-kinase activity,ATP binding,kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIP5K1A itself. We selected most functions PIP5K1A had, and list some proteins which have the same functions with PIP5K1A. You can find most of the proteins on our site.

    Function Related Protein
    1-phosphatidylinositol-4-phosphate 5-kinase activity PIP4K2C,PIP5K1C,PIP5KL1,PIP4K2A,PIKFYVE,PIP4K2B,PIP5K1B
    protein binding NCOR1,METTL13,SLIRP,RAB33A,RPS18,SNCAIP,RPL39L,PGLS,EIF3A,QKI
    ATP binding NLRC4,DCAKD,STK24A,PTK2AB,NLRP5,MSH5,PRPS1L1,SGK1,RRM1,STK35
    kinase binding CEBPA,PRKAA1,HAP1,LDHB,SP100,CAB39,BTG1,PER3,CDC6,PPP1R9B

    Interacting Protein

    PIP5K1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIP5K1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PIP5K1A.

    CADPS;ITGB1BP2;ARL14

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