Pfkfb1
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Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cells
- Sf9 Cells
- E.coli
- HEK293
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
Pfkfb1 involved in several pathways and played different roles in them. We selected most pathways Pfkfb1 participated on our site, such as Fructose and mannose metabolism,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pfkfb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fructose and mannose metabolism | PMM2,AKR1B8,GMPPA,HKDC1,ALDOCB,FBP1,AKR1B7,ALDOAA,ALDOAB,ALDOB |
| AMPK signaling pathway | ADIPOR2,CREB3L2,RAB2A,PRKAB1,PPARG,FBP1,PPP2R5D,MLYCD,FOXO1,IGF1R |
Protein Function
Pfkfb1 has several biochemical functions, for example, 6-phosphofructo-2-kinase activity,ATP binding,fructose-2,6-bisphosphate 2-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Pfkfb1 itself. We selected most functions Pfkfb1 had, and list some proteins which have the same functions with Pfkfb1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRAM1,RPP30,RAB11FIP3,OLFM1,CPSF6,ARHGAP4,ZNF581,IFT46,COL6A2,DNAJC27 |
| 6-phosphofructo-2-kinase activity | PFKFB3,PFKFB4L,PFKFB2A,PFKFB2,PFKFB4 |
| fructose-6-phosphate binding | GCKR,PFKL |
| identical protein binding | GCG,DYNLT3,FTL,MYOM1,LYZ1,PSMA7,ST13,INS2,BLOC1S6,SEPHS1 |
| ATP binding | HSPA7,STK38L,NLRP4B,GKUP,ABL2,STK40,PRKG1A,HLTF,NARS2,DAPK1 |
| fructose-2,6-bisphosphate 2-phosphatase activity | TIGARB,PFKFB3,TIGARA,PFKFB4,C12orf5,PFKFB2 |
| kinase binding | PTPN22,DLG3,DLG1,TRADD,PER1,STRADA,BCL10,BARD1,DUSP12,MIDN |
Interacting Protein
Pfkfb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pfkfb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Pfkfb1.
GCK;PASK;MAPK3
Resources
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References
- Chesney, J; Clark, J; et al. Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. ONCOTARGET 5:6670-6686(2014).
- Yalcin, A; Clem, BF; et al. 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. CELL DEATH & DISEASE 5:-(2014).
