PDS5B
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Official Full Name
PDS5, regulator of cohesion maintenance, homolog B -
Overview
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. -
Synonyms
PDS5B;PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae);androgen induced proliferation inhibitor , APRIN;sister chromatid cohesion protein PDS5 homolog B;AS3;CG008;FLJ23236;KIAA0979;androgen-induced shutoff 3;androgen-induced pro
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PDS5B-1629H | Recombinant Human PDS5B Protein(228-529 aa), His-tagged | E.coli | Human | His | 228-529 aa | |
| APRIN-728H | Recombinant Human APRIN protein, GST-tagged | Wheat Germ | Human | GST |
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| PDS5B-12598M | Recombinant Mouse PDS5B Protein | Mammalian Cells | Mouse | His |
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| PDS5B-2053C | Recombinant Chicken PDS5B | Mammalian Cells | Chicken | His |
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| PDS5B-101HCL | Recombinant Human PDS5B cell lysate | Human | Non |
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| PDS5B-301643H | Recombinant Human PDS5B protein, GST-tagged | E.coli | Human | GST | Met1139-Thr1310 |
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| PDS5B-6616M | Recombinant Mouse PDS5B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PDS5B-6616M-B | Recombinant Mouse PDS5B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PDS5B involved in several pathways and played different roles in them. We selected most pathways PDS5B participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cohesin Loading onto Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDS5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle, Mitotic | CDKN2C,CTDNEP1,CENPP,CEP78,NCAPH,CSNK2A1,PANE1,MYCA,ZW10,H3F3D |
| M Phase | SETA,CENPQ,KIF2B,SET,PMF1,NEK9,NDC80,ZW10,NDEL1B,DSN1 |
| Establishment of Sister Chromatid Cohesion | PDS5A,CDCA5,ESCO2,ESCO1,STAG2,STAG1,WAPAL |
| Cohesin Loading onto Chromatin | NIPBLA,WAPAL,MAU2,NIPBL,STAG2,STAG1,PDS5A,NIPBLB |
| Mitotic Anaphase | DSN1,SGOL2,TMPO,ITGB3BP,PANE1,SPC24,AHCTF1,PMF1,LEMD3,SGOL1 |
| Mitotic Prometaphase | B9D2,NDEL1B,NCAPD2,SKA1,NDEL1A,PDS5A,SKA2,MLF1IP,ERCC6L,CENPP |
| Cell cycle | PMF1,DKC1,RAD1,DMC1,BANF1,CENPW,KIF2B,TCTN2,PLK1,SMC2 |
| Mitotic Metaphase and Anaphase | SGOL1,SPDL1,RANGAP1B,VRK2,SPC24,PDS5A,ZWINT,NSL1,PMF1,ITGB3BP |
Protein Function
PDS5B has several biochemical functions, for example, ATP binding,DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDS5B itself. We selected most functions PDS5B had, and list some proteins which have the same functions with PDS5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | USP5,MED30,GSK3B,WDR61,ACTR1B,GATC,TEX13A,SSX1,PPP1R1A,TMF1 |
| ATP binding | CDC34B,SPS2,EHD3,STK10,CAMK2D1,PTK7,BMPR1B,IKBKB,RIPK4,SCYL2 |
| DNA binding | POLM,DRL,ZNF668,HIST3H3,KLF12,NR5A2,SSRP1A,NR2F6B,HOXB1,FOXJ1A |
Interacting Protein
PDS5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDS5B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDS5B.
RAD21;SMC3;WAPAL
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