PDLIM3
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Official Full Name
PDZ and LIM domain 3 -
Overview
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. This gene is found near a region of chromosome 4 that has been implicated in facioscapulohumeral muscular dystrophy, but this gene does not appear to be involved in the disease. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PDLIM3;PDZ and LIM domain 3;PDZ and LIM domain protein 3;ALP;Actinin associated LIM protein;Actinin-associated LIM protein;Alpha actinin 2 associated LIM protein;Alpha-actinin-2-associated LIM protein;DKFZp686L0362;Enigma homolog;PDLI3_HUMAN;PDLIM 3
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- N-Twin strep and C-His&Flag
- His&Fc&Avi
- His&SUMO
Involved Pathway
PDLIM3 involved in several pathways and played different roles in them. We selected most pathways PDLIM3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDLIM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PDLIM3 has several biochemical functions, for example, cytoskeletal protein binding,protein binding,structural constituent of muscle. Some of the functions are cooperated with other proteins, some of the functions could acted by PDLIM3 itself. We selected most functions PDLIM3 had, and list some proteins which have the same functions with PDLIM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | PHF21B,AMZ2,TRIM31,LMO4B,ARIH1L,TRIM5,ZFP276,RNF220,DNAJC21,PMPCB |
| cytoskeletal protein binding | FRMD5,ACTN2,PACSIN1A,PTPN4,PACSIN2,SLC8A1,CAPN1,MSNB,EPB4.1L4A,EZRB |
| structural constituent of muscle | MYL1,MYL6B,MYBPC2,MYOT,COX4I2,MYBPC1,MYL5,MYBPH,ACTN2,SYNM |
| protein binding | TYROBP,RTN4RL1B,TDP1,SPHK1,DUSP5,LINGO1B,EXOC3L,PRDM5,RARRES3,NOS3 |
Interacting Protein
PDLIM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDLIM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDLIM3.
ACTN2;RYR1;RANBP2;FHL1;MYPN;MYOZ3;PALLD;MYOZ2;MYOT
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