PDE4D
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Official Full Name
phosphodiesterase 4D, cAMP-specific -
Overview
This gene encodes one of four mammalian counterparts to the fruit fly dunce gene. The encoded protein has 3,5-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009] -
Synonyms
PDE4D;phosphodiesterase 4D, cAMP-specific;DPDE3;PDE43;STRK1;ACRDYS2;HSPDE4D;PDE4DN2;cAMP-specific 3,5-cyclic phosphodiesterase 4D;cAMP-specific phosphodiesterase PDE4D6;phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Recombinant Proteins
- Human
- Dog
- Rat
- Mouse
- E.coli
- Insect Cell
- Sf9 insect cells
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- GST
- His&GST
- Non
- His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PDE4D involved in several pathways and played different roles in them. We selected most pathways PDE4D participated on our site, such as Purine metabolism,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | GRIA3,CALM4,CALML5,PPP1CB,GNAI2,RAC2,VAV2,PRKACA,ATP1B1,GPR81 |
| Purine metabolism | AK8,PNP5A,HPRT1,ADCY1A,PRPS1A,HDDC3,NT5C1BA,IMPDH1A,ADAL,PDE6B |
Protein Function
PDE4D has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity,3,5-cyclic-nucleotide phosphodiesterase activity,ATPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4D itself. We selected most functions PDE4D had, and list some proteins which have the same functions with PDE4D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | TRIM27,ZFP184,TRIM55B,ARFGAP2,TNNI3,ZNF227,MSRB1A,RPS27.1,TKT,CIT |
| scaffold protein binding | NLRP1,NOS3,NLGN4Y,PANX1,KRT18,VIM,KCNH2,DSP,CHRNA7,CASP8 |
| ATPase binding | TCIRG1,ESR1,ABCA1,TAF9,ATP6V0A4,DERL1,ATXN3,ATP6V0A1A,NUFIP1,DRD1 |
| 3,5-cyclic-AMP phosphodiesterase activity | USB1,PDE3A,PDE8B,PDE4C,PDE1B,PDE8A,TDP2B,PDE7A,PDE4A,PDE7B |
| drug binding | PDXK,NR1I2,GRIK1,GSTP2,MTOR,PPP3CA,HMGCS1,PPARG,ADH1,CYP2D6 |
| SH3 domain binding | SHANK2,EVL,DNAJC6,GRIK5,CD3E,ARHGAP31,EVLB,SHANK3,ARHGAP6,RAD9 |
| protein binding | WHRN,SREBF2,KRR1,OLFM3,PLUNC,C16orf59,C1QTNF3,NUP35,IL36RN,NR2F2 |
| cAMP binding | HCN4,PDE3A,RAPGEF4,CNGA2,BVES,PDE4B,PRKAR2B,PDE2A,RAPGEF3,PRKAR1A |
| 3,5-cyclic-nucleotide phosphodiesterase activity | PDE6D,PDE8B,PDE3B,PDE8A,PDE11A,PDE5A,PDE9A,PDE10A,PDE5AB |
Interacting Protein
PDE4D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4D here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4D.
COIL;MAGEA6;GOLGA8F;GOLGA8DP;TRAF1;Bub1;AKAP12;SHANK2;q8d0r7_yerpe;ARRB2
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References
- Nagasaki, K; Iida, T; et al. PRKAR1A Mutation Affecting cAMP-Mediated G Protein-Coupled Receptor Signaling in a Patient with Acrodysostosis and Hormone Resistance. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 97:E1808-E1813(2012).
- Dostaler-Touchette, V; Bedard, F; et al. Cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase is functional in bovine mammary gland. JOURNAL OF DAIRY SCIENCE 92:3757-3765(2009).
