Pcolce
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Official Full Name
procollagen C-endopeptidase enhancer -
Overview
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008] -
Synonyms
PCOLCE;procollagen C-endopeptidase enhancer;PCPE;PCPE1;PCPE-1;procollagen C-endopeptidase enhancer 1;procollagen C-proteinase enhancer 1;procollagen COOH-terminal proteinase enhancer 1;type 1 procollagen C-proteinase enhancer protein;type I procollagen COOH-terminal proteinase enhancer;procollagen, type 1, COOH-terminal proteinase enhancer
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Non
- S
- T7
- Avi
- Fc
- DDK
- Myc
Involved Pathway
Pcolce involved in several pathways and played different roles in them. We selected most pathways Pcolce participated on our site, such as Assembly of collagen fibrils and other multimeric structures,Collagen biosynthesis and modifying enzymes,Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pcolce were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | LOXL4,COMP,P3H2,PCOLCE2,CTSB,PCOLCEB,COL15A1B,CRTAP,SERPINH1,JAM2B |
| Assembly of collagen fibrils and other multimeric structures | COL10A1A,CD151,COL4A4,LOX,COL6A2,COL6A3,COL11A1B,TLL1,BMP1,MMP13 |
| Collagen formation | COL9A1,LOXL1,CTSS,COL25A1,COL5A3B,COL2A1,PRP,ADAMTS2,COL5A1,COL23A1 |
| Crosslinking of collagen fibrils | TLL2,BMP1A,BMP1B,LOX,LOXL2,LOXL3,LOXL4,BMP1,ABHD1,LOXL1 |
| Collagen biosynthesis and modifying enzymes | LEPREL1,COL28A1A,CRTAP,COL4A4,COL6A1,COL17A1A,TLL1,COL8A1A,COL28A1D,COL8A1 |
Protein Function
Pcolce has several biochemical functions, for example, collagen binding,heparin binding,peptidase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Pcolce itself. We selected most functions Pcolce had, and list some proteins which have the same functions with Pcolce. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ACP1,CTNND1,GABBR1,SMAD3A,ADRA2C,TF,ITGA2,C1orf182,HDGF2,YWHAQ |
| peptidase activator activity | MMP25,FN1,PCOLCE2,CAV1,FBLN1,APP,CLPX,PINK1,PSME4,MMP14 |
| heparin binding | HBEGF,PTCH1,ELANE,NRP1,CXCL6,EPYC,CHRD,SMOC2,VEGFAA,Itgam&Itgb2 |
| collagen binding | SERPINH1A,MMP9,Pdgfa&Pdgfb,ABI3BP,NID1,TLL1,SMAD7,PODN,ITGA1,SERPINH1B |
Interacting Protein
Pcolce has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pcolce here. Most of them are supplied by our site. Hope this information will be useful for your research of Pcolce.
COL18A1;lm-111_human_complex;collagen_vi_human;APP;THBS1;hyaluronan;chondroitin_sulfate;dermatan_sulfate;heparin;heparan_sulfate;collagen_iv_human-3_complex
Resources
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References
- Raz, V; Sterrenburg, E; et al. Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy. BMC NEUROLOGY 13:-(2013).
- Goldsmith, EC; Bradshaw, AD; et al. Cellular Mechanisms of Tissue Fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 304:C393-C402(2013).
