PCBP2
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Official Full Name
poly(rC) binding protein 2 -
Overview
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PCBP2;poly(rC) binding protein 2;poly(rC)-binding protein 2;heterogenous nuclear ribonucleoprotein E2;hnRNP E2;HNRPE2;alpha-CP2;heterogeneous nuclear ribonucleoprotein E2;hnRNP-E2;MGC110998
Recombinant Proteins
- Human
- Zebrafish
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Myc
- His&Fc&Avi
- Flag
Involved Pathway
PCBP2 involved in several pathways and played different roles in them. We selected most pathways PCBP2 participated on our site, such as Gene Expression,Immune System,Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA Splicing | HNRNPA0B,HNRPL,HNRNPD,YBX1,HNRNPR,RBM5,HNRNPH1L,PDCD7,RNPC3,SNRNP25 |
| mRNA Splicing - Major Pathway | HNRNPA0L,DNAJC8,PTBP1A,BCAS2,PRPF8,SUGP1,SF3A1,HNRNPA2B1,HNRNPUL1,HNRNPH2 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | TAX1BP1,TAX1BP1B,HERC5,RNF216,NLRC5,RNF135,TANK |
| Immune System | ERAP2,SH3RF1,RNF216,SIRPB1,FCN2,EIF4G2,GZMM,FCN3,Siglece,ASB4 |
| Negative regulators of RIG-I/MDA5 signaling | HERC5,NLRC5,TAX1BP1B,RNF135,TAX1BP1,CYLD,RNF216 |
| Innate Immune System | TXNIP,BFB,CTS7,ABI1,FAM49BA,WASF3,BTR18,WIPF2,DEFA6,BTR09 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPL2,CSTF2,NXF1,PRPF8,CLP1,BCAS2,NUDT21,SF3A1,CD2BP2,PTBP1B |
| Gene Expression | ZBTB8OS,COX14,COBRA1,ESR2B,C2orf49,ZNF286A,ZNF205,ZNF41,NR2F1A,NR1I2 |
Protein Function
PCBP2 has several biochemical functions, for example, DNA binding,RNA binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCBP2 itself. We selected most functions PCBP2 had, and list some proteins which have the same functions with PCBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | GSK3B,MC1R,BAG4,TNFRSF1B,CUL4B,EGFR,NKD2,YWHAE,GPI1,TRIM28 |
| poly(A) RNA binding | LARP2,CDK11B,DDX17,DDX41,RTF1,MAGOH2,RPS3A,MRPL22,RBM19,RPL31 |
| DNA binding | E4F1,HES1,H2AFB2,STAT2,FOXN1,CEBPZ,SLC2A4RG,EOMESB,SOX21A,TOP3A |
| enzyme binding | PHKG2,PLAUR,KRT79,PIAS3,SUPT5H,FOXO4,CBX3,PARP1,ZFHX3,DVL1 |
| RNA binding | ATXN2,NHP2L1A,ZFML,U2SURP,RALY,RBM24A,THOC2,LIN28A,NOL3,PPIE |
| protein binding | CNOT6L,SSTR3,DNTTIP1,ADAP1,OXR1,GNAI3,MED8,TPCN2,CALB1,PSMB10 |
Interacting Protein
PCBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCBP2.
SRSF3;SNRPA;PABPC1;q12771_human;PCBP1;cebpa-uorf
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References
- Lopez-Manriquez, E; Vashist, S; et al. Norovirus Genome Circularization and Efficient Replication Are Facilitated by Binding of PCBP2 and hnRNP A1. JOURNAL OF VIROLOGY 87:11371-11387(2013).
- Wang, LY; Jeng, KS; et al. Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5 ' Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome. JOURNAL OF VIROLOGY 85:7954-7964(2011).
