PABPC1
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Official Full Name
poly(A) binding protein, cytoplasmic 1 -
Overview
Poly(A)-binding protein 1 (PABP1) associates with the 3 poly(A) tail of mRNA and also eIF4F. eIF4F is a complex whose functions include the recognition of the mRNA 5 cap structure (eIF4E), delivery of an RNA helicase to the 5 region (eIF4A), bridging of t -
Synonyms
PABPC1;poly(A) binding protein, cytoplasmic 1;PAB1, PABPC2, poly(A) binding protein, cytoplasmic 2;polyadenylate-binding protein 1;PABP1;PABPL1;poly(A) binding protein, cytoplasmic 2;PAB1;PABP;PABPC2
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rhesus macaque
- Rat
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- N-Twin strep and C-His&Flag
- Flag
- His&Fc&Avi
- His&SUMO
Involved Pathway
PABPC1 involved in several pathways and played different roles in them. We selected most pathways PABPC1 participated on our site, such as RNA transport,mRNA surveillance pathway,RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PABPC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | UBE2I,SUMO3,PNN,EIF3EA,PAIP1,CYFIP2,RPP14,NMD3,EIF4A1B,EIF2S3Y |
| mRNA surveillance pathway | PPP2R1B,DAZAP1,PPP2CA,PPP2R1A,PPP2R2A,ETF1,SSU72,PABPN1L,MAGOHB,MAGOH2 |
| RNA degradation | XRN2,EXOSC3,PFKL,EXOSC8,PFKMB,LSM8,EDC3,DDX6,HSPD1,CNOT4 |
Protein Function
PABPC1 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding,poly(A) binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PABPC1 itself. We selected most functions PABPC1 had, and list some proteins which have the same functions with PABPC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | HIST2H4,RPL13,APOBEC3F,RPS8,NOVA1,MBNL1,EIF1B,PARN,BRIX1,REXO4 |
| poly(U) RNA binding | PNPT1,KHDRBS2,DIS3L2,PATL1,RBM11,HNRNPH1,HNRNPC,PABPC4,KHDC1A,MSI1 |
| translation activator activity | LARP1,DAZL,BOLL,ABCF1,PAIP1,RPS27L |
| poly(A) binding | PABPC4,HNRNPDL,DDX3X,TIA1,RBPMS,PABPC3,KHDRBS1,ZC3H14,SYNCRIP,KHDRBS2 |
| protein binding | XIAP,CRTAC1,SLA2,FANCC,PMP22,SELS,SAC3D1,SIPA1L2,TBC1D10A,MED9 |
| nucleotide binding | SMYHC2,RBM4.1,DNM1B,STK38A,Fert2,NEK5,YTHDC2,RBFOX1L,OXSR1B,RHOGB |
| protein C-terminus binding | SAE1,ITPR1,CLIC6,ATXN2,TOP2A,PHB2,HSPB7,ATF4,PIAS3,JAK2 |
Interacting Protein
PABPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PABPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PABPC1.
TNRC6C;PAIP1
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