OSCAR
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Official Full Name
osteoclast associated, immunoglobulin-like receptor -
Overview
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
OSCAR;osteoclast associated, immunoglobulin-like receptor;osteoclast-associated immunoglobulin-like receptor;hOSCAR;hOSCARM2;hOSCARM3;mOSCAR;Oscar protein;OSCAR_HUMAN;OSCARS1;OSCARS2;Osteoclast associated immunoglobulin like receptor;Osteoclast associated receptor;Osteoclast-associated receptor;PIgR-3;PIGR3;Poly Ig receptor 3;Poly-Ig receptor 3;Polymeric immunoglobulin receptor 3;OTTHUMP00000067447;OTTHUMP00000067448;OTTHUMP00000067450;OTTHUMP00000067451;OTTHUMP00000067452;OTTHUMP00000067460;OTTHUMP00000081759;polymer
Recombinant Proteins
- Human
- Mouse
- Insect Cell
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- Protein Conjugation
- HEK293T
- His
- Non
- Fc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
OSCAR involved in several pathways and played different roles in them. We selected most pathways OSCAR participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSCAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | MAPK10,CALCR,FOS,MAP2K7,IFNGR2,PIK3R2,IKBKG,IFNGR1,STAT2,IFNG |
| Adaptive Immune System | KLB,EGF,AKT3,FGFR1B,AP1S3A,SEC23A,FRS2B,AP2A1,MICA,FGF20A |
| Immune System | SEC61B,LILRB3,NLRP3,PIK3AP1,BTR09,FBXO27,BTR02,FCN2,ALCAMB,IL1RN |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | LILRB5,CD200R3,SIGLEC9,SIGLEC11,GM11711,KLRB1A,LILRA1,RAET1E,SLAMF6,LILRA2 |
Protein Function
OSCAR has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by OSCAR itself. We selected most functions OSCAR had, and list some proteins which have the same functions with OSCAR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
OSCAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSCAR here. Most of them are supplied by our site. Hope this information will be useful for your research of OSCAR.
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Resources
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References
- Varin, A; Pontikoglou, C; et al. CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human. PLOS ONE 8:-(2013).
- Shirai, H; Ikeda, K; et al. High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 82:1624-1635(2014).
