ONECUT2
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Official Full Name
one cut homeobox 2 -
Overview
This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. -
Synonyms
ONECUT2;one cut homeobox 2;one cut domain, family member 2;one cut domain family member 2;OC 2;Transcription factor ONECUT 2;Transcription factor ONECUT2;HGNC:8139;MGC120377;MGC120378;OC2;ONECUT 2;ONECUT 2 homeodomain transcription factor;ONECUT 2 protein;ONECUT2 homeodomain transcription factor;ONECUT2 protein;HNF-6-beta;OTTHUMP00000216457;transcription factor ONECUT-2;hepatocyte nuclear factor 6-beta;ONECUT-2 homeodomain transcription factor;OC-2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ONECUT2-1459H | Recombinant Human ONECUT2, GST-tagged | E.coli | Human | GST | 226-332aa | |
| ONECUT2-3539H | Recombinant Human ONECUT2 protein, His-tagged | E.coli | Human | His | 226-332 aa | |
| ONECUT2-12154M | Recombinant Mouse ONECUT2 Protein | Mammalian Cell | Mouse | His |
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| ONECUT2-19HCL | Recombinant Human ONECUT2 HEK293T cell lysate | HEK293T | Human | Myc&DDK |
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| ONECUT2-6392M | Recombinant Mouse ONECUT2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ONECUT2-6392M-B | Recombinant Mouse ONECUT2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ONECUT2 involved in several pathways and played different roles in them. We selected most pathways ONECUT2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ONECUT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ONECUT2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ONECUT2 itself. We selected most functions ONECUT2 had, and list some proteins which have the same functions with ONECUT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ASCL2,SOX1,ZFP639,ZKSCAN3,ZIC3,NFIB,TXK,MYF5,ESRRA,CREB3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | HOXC13,CRX,HNRNPK,TP73,LEF1,SOX12,MEF2C,SPI1,RELA,SMAD2 |
Interacting Protein
ONECUT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ONECUT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ONECUT2.
Resources
Research Area
Hepatic Progenitor Cell Transcription FactorsHepatic and Pancreatic Progenitor Cell Transcription Factors
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References
