NXT1
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Official Full Name
NTF2-like export factor 1 -
Overview
The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. -
Synonyms
NXT1;NTF2-like export factor 1;NTX2 like export factor1;NTF2-related export protein 1;MTR2;P15;NTF2 like export factor 1;NTF2 related export protein 1;NUTF like export factor 1;NXT1_HUMAN;Protein P15;OTTHUMP00000030420;NTX2-like export factor1;NUTF-like export factor 1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- T7
- His
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NXT1 involved in several pathways and played different roles in them. We selected most pathways NXT1 participated on our site, such as Ribosome biogenesis in eukaryotes,RNA transport,mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NXT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Influenza A | PIK3R1,IFNA21,KPNA1,IL8L1,MAP2K6,TNFRSF10D,MAPK11,CCL5,IFNB1,HSPA1L |
| RNA transport | THOC1,PABPC1,NUP93,NUP88,DDX39B,NUP85,EIF4A1A,EIF3JB,UPF3A,SIP1 |
| Ribosome biogenesis in eukaryotes | HEATR1,NOL6,NXF3,MPHOSPH10,NXF2,PWP2H,FCF1,RAN,PWP2,POP1 |
| mRNA surveillance pathway | PNN,PPP2R5CB,PABPC1,WDR33,CPSF3,NCBP1,PABPC1A,CPSF7,PPP2R1B,PPP2R2D |
Protein Function
NXT1 has several biochemical functions, for example, Ran GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NXT1 itself. We selected most functions NXT1 had, and list some proteins which have the same functions with NXT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C1orf105,STAU2,IL2RB,HIST1H4A,TCF7L1A,GPI1,TXNDC11,CHD8,SPSB1,PDCD2 |
| Ran GTPase binding | RANGAP1,TNPO2,TNPO1,RANBP3,IPO8,CSE1L,XPO7,XPOT,IPO13,RANGRF |
Interacting Protein
NXT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NXT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NXT1.
NXF1;NXF3;STAU1;PAXIP1;Ranbp21;CHTOP
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